The antileishmanial activity of xanthohumol is mediated by mitochondrial inhibition
SUMMARYXanthohumol (Xan) is a natural constituent of human nutrition. Little is known about its actions on leishmanial parasites and their mitochondria as putative target. Therefore, we determined the antileishmanial activity of Xan and resveratrol (Res, as alternative compound with antileishmanial activity) with respect to mitochondria inLeishmania ...
LIANET MONZOTE +6 more
openaire +3 more sources
Xanthohumol and echinocystic acid induces PSTVd tolerance in tomato
Tomato is a popular vegetable worldwide; its production is highly threatened by infection with the potato spindle tuber viroid (PSTVd). We obtained the full‐length genome sequence of previously conserved PSTVd and inoculated it on four genotypes of semi ...
Wenkun Tang +6 more
doaj +1 more source
Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling [PDF]
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen.
A Arfe +60 more
core +4 more sources
The aim of this in vitro study was to evaluate the effect of xanthohumol and thymol on the impact of Candida albicans on the structure, size and cell viability of subgingival biofilms formed on dental implant surfaces. The structure and microbial biomass
Enrique Bravo +3 more
doaj +1 more source
Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society [PDF]
Wild edible plants (WEPs) are part of the cultural and genetic heritage of different regions of the world. In times of famine and scarcity, these sources of nutrients and health-promoting compounds have received high importance mainly in rural and ...
Abbasi +183 more
core +1 more source
Prenylated Flavonoids as Valuable Biologically Active Compounds from Hops
Hop cones contain a number of important compounds, which are frequently used in the brewing industry. Recently, an increasing interest has been raised in using hops also for other purposes, particularly in the pharmaceutical industry.
Jan Nešpor +4 more
doaj +1 more source
Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial [PDF]
Background: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However,
Aros, Fernando +20 more
core +1 more source
Diphenyldifluoroketone EF24 Suppresses Pro-inflammatory Interleukin-1 receptor 1 and Toll-like Receptor 4 in lipopolysaccharide-stimulated dendritic cells [PDF]
BACKGROUND: Unresolved and prolonged inflammation is a pathological basis of many disorders such as cancer and multiple organ failure in shock. Interleukin-1 receptor (IL-1R) superfamily consists of IL-1R1 and pathogen pattern recognition receptor toll ...
Geeta Rao +3 more
core +1 more source
O papel dos estrogénios e vias de sinalização do recetor de estrogénio no cancro e infertilidade associados a schistosomose [PDF]
O Schistosoma haematobium é um verme parasita que infecta mais de 100 milhões de indivíduos, principalmente no mundo em desenvolvimento. É o agente causador da schistosomose urogenital e tem sido associado com alta incidência de carcinoma de células ...
Botelho, Mónica C.
core
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants [PDF]
The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-RING E3 ubiquitin ligase (CRL) multisubunit protein complex.
Canning, Peter +2 more
core +3 more sources

