Results 121 to 130 of about 5,333 (223)

Xanthohumol overcomes osimertinib resistance via governing ubiquitination-modulated Ets-1 turnover

Cell Death Discovery
Non-small cell lung cancer (NSCLC) is a prevalent and fatal malignancy with a significant global impact. Recent advancements have introduced targeted therapies like tyrosine kinase inhibitors (TKIs) such as osimertinib, which have improved patient ...
Ying Ma, Ruirui Wang, Jinzhuang Liao, Pengfei Guo, Qiang Wang, Wei Li   +5 more
doaj   +1 more source

Exploring the inhibitory potential of xanthohumol on MEK1/2: a molecular docking and dynamics simulation investigation

Research in Pharmaceutical Sciences
Background and purpose: Xanthohumol (Xn), a small molecule found in Humulus lupulus, has shown promise as an anti-cancer compound. This in silico study was performed to understand the mechanism of action of Xn as a natural compound on MEK1/2 by ...
Zohreh Gholizadeh Siahmazgi, Shiva Irani, Ali Ghiaseddin, Fereshteh Soutodeh, Zahra Gohari, Jaber Afifeh, Amirreza Pashapouryeganeh, Hilda Samimi, Mahmood Naderi, Parviz Fallah, Vahid Haghpanah   +10 more
doaj   +1 more source

Xanthohumol and Breast cancer

Introdução: O câncer de mama é um dos mais prevalentes entre as mulheres, apresentando desafios significativos no tratamento. O Xanthohumol (XN) tem demonstrado propriedades quimio-preventivas e quimioterápicas promissoras contra células de câncer de mama.
openaire   +2 more sources

Xanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway

Drug Design, Development and Therapy, 2020
Chuanhao Jiang,1,2,* Ning Xie,3,* Taoli Sun,4 Wanjun Ma,2 Bikui Zhang,2 Wenqun Li2 1Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Department of ...
Jiang C, Xie N, Sun T, Ma W, Zhang B, Li W   +5 more
doaj  

THE IMPACT OF PLANT PROTECTION AND FERTILIZATION ON CONTENT OF BIOACTIVE SUBSTANCES IN ORGANIC HOPS

Acta Scientiarum Polonorum: Hortorum Cultus, 2015
 Hop (Humulus lupulus) is one of the basic raw materials employed in brewing. All hops secondary metabolites exhibit pronounced bioactive effects. Therefore beer is the most important source of hop bioactive compounds in the human diet.
Ewa Solarska, Bożena Sosnowska
doaj  

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads [PDF]

, 2016
Several compounds bearing the indolinone chemical scaffold are known to possess anticancer properties. For example, the tyrosine kinase inhibitor sunitinib is an arylideneindolin-2-one compound.
Arner, ES, Bertrand, HC, Chen, W, Cheng, Q, Chew, EH, Kaminska, KK, Stafford, WC, Tajima, H, Wells, G   +8 more
core  

Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma [PDF]

, 2017
Giant cadherin FAT1 is increased in HCC and is a protumorigenic factors in HCC ...
Bosserhoff, Anja-Katrin, Czech, Barbara, Hartmann, Arndt, Hellerbrand, Claus, Ikenberg, Kristian, Müller, Martina, Oefner, Peter J., Spruss, Thilo, Valletta, Daniela, Weiss, Thomas S., Wild, Peter   +10 more
core  

Xanthohumol [PDF]

, 2020
openaire   +1 more source

Components Analysis and Classification of Beer and White Spirit Based on NMR Approach [PDF]

, 2016
食品是人类生活中一类重要的必需品，各种食品具有不同的特性和成分，直接关系人体的健康。近年来，我国食品安全问题受到社会公众群体的广泛关注。核磁共振(NMR)技术相比于其他传统的检测方法，具有对样品的制备要求低、预处理简单，无损检测和高灵敏度等特点，在食品科学研究中得到广泛应用。 酒精类饮料属液态食品，啤酒更是继水、茶之后世界第三大饮用品，白酒则是中国特有酒种。目前基于NMR技术对啤酒的研究多停留在定性分析，化学成分的描述一般只针对某类化合物，对总体化学成分的全面研究较少。而基于NMR的白酒研究集中在国内 ...
栾晓菲
core  

Branchen im Blickpunkt: Anmerkungen und Daten zum Weltbiermarkt [PDF]

Im Jahr 2004 ist die Bierproduktion weltweit im Vergleich zum Vorjahr um 4,8% angestiegen, in Europa verlief das Wachstum mit 2,5% unterdurchschnittlich, und in Deutschland wurde ein Rückgang um 1,2% beobachtet.
Matthias Balz
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