Results 11 to 20 of about 11,180 (215)

Xanthone Glucosides: Isolation, Bioactivity and Synthesis

Molecules, 2021
Xanthones are secondary metabolites found in plants, fungi, lichens, and bacteria from a variety of families and genera, with the majority found in the Gentianaceae, Polygalaceae, and Clusiaceae. They have a diverse range of bioactivities, including anti-
Qing Huang, Youyi Wang, Huaimo Wu, Man Yuan, Changwu Zheng, Hongxi Xu   +5 more
doaj   +2 more sources

Molecular Docking and Molecular Dynamic Investigations of Xanthone-Chalcone Derivatives against Epidermal Growth Factor Receptor for Preliminary Discovery of Novel Anticancer Agent

Indonesian Journal of Chemistry
Epidermal growth factor receptor (EGFR) is found to be overexpressed in cancer cells as it controls angiogenesis, cell signaling, and proliferation mechanisms.
Yehezkiel Steven Kurniawan, Ervan Yudha, Gerry Nugraha, Nela Fatmasari, Harno Dwi Pranowo, Jumina Jumina, Eti Nurwening Sholikhah   +6 more
doaj   +2 more sources

Quantitative structure–activity relationship (QSAR) and molecular docking of xanthone derivatives as anti-tuberculosis agents

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2020
Quantitative structure–activity relationship (QSAR) and molecular docking approach were carried out to design novel anti-tuberculosis agents based on xanthone derivatives.
Emmy Yuanita, Sudirman, Ni Komang Tri Dharmayani, Maria Ulfa, Jufrizal Syahri   +4 more
doaj   +2 more sources

LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Mangosteen is one of the best tasting tropical fruit widely cultivated in Southeast Asia. This study aimed to quantify xanthone content in different parts of Garcinia mangostana by LC-QTOF-MS and determine its influence on their cholinesterase inhibitory
Kooi Yeong Khaw, Chun Wie Chong, Vikneswaran Murugaiyah   +2 more
doaj   +2 more sources

Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations

Molecules, 2019
Following our previous work on the antitumor activity of acetylated flavonosides, a new acetylated xanthonoside, 3,6-bis(2,3,4,6-tetra-O-acetyl-β-glucopyranosyl)xanthone (2), was synthesized and discovered as a potent inhibitor of tumor cell growth.
Ana Alves, Marta Correia-da-Silva, Claúdia Nunes, João Campos, Emília Sousa, Patrícia M. A. Silva, Hassan Bousbaa, Francisca Rodrigues, Domingos Ferreira, Paulo C. Costa, Madalena Pinto   +10 more
doaj   +2 more sources

Quantification of Xanthone and Anthocyanin in Mangosteen Peel by UPLC-MS/MS and Preparation of Nanoemulsions for Studying Their Inhibition Effects on Liver Cancer Cells

International Journal of Molecular Sciences, 2023
Mangosteen peel, a waste produced during mangosteen processing, has been reported to be rich in xanthone and anthocyanin, both of which possess vital biological activities such as anti-cancer properties.
Rui Li, B. Inbaraj, Bing‐Huei Chen
semanticscholar   +1 more source

Mangostanin, a Xanthone Derived from Garcinia mangostana Fruit, Exerts Protective and Reparative Effects on Oxidative Damage in Human Keratinocytes

Pharmaceuticals, 2022
The fruit of Garcinia mangostana (mangosteen) is known in ancient traditional Asian medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer activities. These effects are mainly due to the action of polyphenols known as xanthones,
M. Abate, Cristina Pagano, M. Masullo, M. Citro, S. Pisanti, S. Piacente, M. Bifulco   +6 more
semanticscholar   +1 more source

Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation

Nature Communications, 2022
Xanthone-containing natural products display diverse pharmacological properties. The biosynthetic mechanisms of the xanthone formation have not been well documented.
Chunfang Yang, Liping Zhang, Wenjun Zhang, Chunshuai Huang, Yiguang Zhu, Xiaodong Jiang, Wei Liu, Mengran Zhao, B. C. De, Changsheng Zhang   +9 more
semanticscholar   +1 more source

Natural and Synthetic Xanthone Derivatives Counteract Oxidative Stress via Nrf2 Modulation in Inflamed Human Macrophages

International Journal of Molecular Sciences, 2022
Natural products have attracted attention due to their safety and potential effectiveness as anti-inflammatory drugs. Particularly, xanthones owning a unique 9H-xanthen-9-one scaffold, are endowed with a large diversity of medical applications, including
M. Gallorini, S. Carradori, D. Resende, L. Saso, A. Ricci, Andreia Palmeira, A. Cataldi, M. Pinto, E. Sousa   +8 more
semanticscholar   +1 more source

New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
Zi Han Loh, Huey Chong Kwong, K. Lam, S. Teh, G. Ee, C. Quah, A. Ho, S. Mah   +7 more
semanticscholar   +1 more source