Results 61 to 70 of about 15,472 (254)

Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple‐Negative Breast Cancer Through Canonical Wnt Signaling

Food Frontiers, Volume 7, Issue 3, May 2026.
Garcinone C (Gar. C), a xanthone derived from mangosteen (Garcinia mangostana), suppresses triple‐negative breast cancer growth and stemness by inducing mitochondrial‐mediated apoptosis and inhibiting the Wnt/β‐catenin pathway, highlighting its potential as a natural compound for the prevention and treatment TNBC.
Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen   +4 more
wiley   +1 more source

ABC Index Analysis: Physical Properties of Prenylated Xanthone

Jurnal Diferensial
Xanthone is a heterocyclic compound with various substituents (hydroxy, prenyl, geranyl, methoxy, halogens, and others). The presence of these substituents contributes to diverse biological activities, including anticancer, antidiabetic, and antioxidant
Lia Fitta Pratiwi, Ardelia Mufarrihati, Ni Komang Tri Dharmayani, I Gede Adhitya Wisnu Wardhana   +3 more
doaj   +1 more source

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

Pharmaceuticals, 2021
The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible.
Yehezkiel Steven Kurniawan, Krisfian Tata Aneka Priyangga, Jumina, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Abdul Karim Zulkarnain, Hana Anisa Fatimi, Jeffry Julianus   +7 more
doaj   +1 more source

Pedicularis L. Genus. Systematics, botany, phytochemistry, chemotaxonomy, ethnopharmacology, and other [PDF]

, 2019
In this review, the relevance of the plant species belonging to the Pedicularis L. genus has been considered from different points of view. Particular emphasis was given to phytochemistry and ethnopharmacology, since several classes of natural compounds ...
Bianco, Armandodoriano, Ciccòla, Alessandro, De Vita, Daniela, Foddai, Sebastiano, Franceschin, Marco, Frezza, Claudio, Guiso, Marcella, Nicoletti, Marcello, Serafini, Ilaria, Serafini, Mauro, Tomassini, Lamberto, Toniolo, Chiara, Venditti, Alessandro, Ventrone, Antonio   +13 more
core   +1 more source

Antiprotozoal Activity of Xanthone Derivatives

Orbital: The Electronic Journal of Chemistry, 2020
A series of xanthone derivatives containing different side chains, including ω-bromo and ω-aminoalkoxylxanthones (with linear alkoxy chains of 3, 4 and 5 carbon atoms and methyl, propyl, tert-butylamino and piperidinyl moieties), synthesized from the ...
Ana Camila Micheletti, Neli Kika Honda, Paola Dias de Oliveira, Dênis Pires de Lima, Adilson Beatriz, Sergio de Albuquerque   +5 more
doaj   +3 more sources

The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors

Molecules, 2018
Upregulation of phosphoglycerate mutase 1 (PGAM1) has been identified as one common phenomenon in a variety of cancers. Inhibition of PGAM1 provides a new promising therapeutic strategy for cancer treatment.
Penghui Wang, Lulu Jiang, Yang Cao, Deyong Ye, Lu Zhou   +4 more
doaj   +1 more source

Synthesis of Xanton From 2-phenoxybenzoic Acid as a Base Material for New Malaria Drugs [PDF]

, 2013
Synthesis of xanthone was conducted from the raw material of 2-phenoxybenzoic acid through acid-catalyzed-cyclization. The product was characterized using UV- Vis, 1 13 d FT-IR, H-NMR, C-NMR, an LC-MS Cyclization of 2-phenoxybenzoic acid using sulfuric ...
Amanatie, A. (Amanatie), Hanafi, M. (M), Jumina, J. (Jumina), Mustofa, M. (Mustofa)   +3 more
core  

Xanthones from Polygala alpestris (Rchb.)

Zeitschrift für Naturforschung C, 2004
Bioactivity-guided fractionation of Polygala alpestris L. (Rchb.) extracts led to the identification of two new xanthones, 1,3,7-trihydroxy-2,6-dimethoxyxanthone (1) and 2,3-methylenedioxy-4,7-dihydroxyxanthone (2). In addition five known compounds 3,4-dimethoxy-1,7-dihydroxyxanthone (3), 1,3-dihydroxy-7-methoxyxanthone (4), 1,7-dihydroxy-2,3 ...
Dall'Acquaa, Stefano, Viola, Giampietro, Cappelletti, Elsa Mariella, Innocenti, Gabbriella   +3 more
openaire   +3 more sources

Antitumor Activity of Some Prenylated Xanthones [PDF]

Pharmaceuticals, 2009
Pyranoxanthones 6-8 were obtained by dehydrogenation of the respective dihydropyranoxanthones 3-5 with DDQ in dry dioxane. Two prenylated xanthones 10,11 were obtained from the reaction of 1-hydroxyxanthone (9) with prenyl bromide in alkaline medium, or by condensation of xanthone 9 with isoprene in the presence of orthophosphoric acid.
Raquel A.P. Castanheiro, Artur M.S. Silva, Naïr A.N. Campos, Maria S.J. Nascimento, Madalena M.M. Pinto   +4 more
openaire   +4 more sources

Cytotoxicity and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos

Toxics, 2018
Xanthone is an organic compound mostly found in mangosteen pericarp and widely known for its anti-proliferating effect on cancer cells. In this study, we evaluated the effects of xanthone crude extract (XCE) and α-mangostin (α-MG) on normoxic
Shazrul Fazry, Muhammad Akram Mohd Noordin, Salahuddin Sanusi, Mahanem Mat Noor, Wan Mohd Aizat, Azwan Mat Lazim, Herryawan Ryadi Eziwar Dyari, Nur Hidayah Jamar, Juwairiah Remali, Babul Airianah Othman, Douglas Law, Nik Marzuki Sidik, Yew Hoong Cheah, Yi Chieh Lim   +13 more
doaj   +1 more source