Results 1 to 10 of about 26,774 (163)

Intact corticostriatal function in aged system xc - - deficient mice [PDF]

Translational Psychiatry
System xc - (with xCT as specific subunit) is an astrocytic cystine/glutamate antiporter that constitutes the major source of extracellular glutamate in the mouse striatum.
Laura De Pauw, Agnès Villers, Cindy Moore, Olaya Lara, Océane Vanonckelen, Lise Verbruggen, Hideyo Sato, Eduard Bentea, Lutgarde Arckens, Laurence Ris, Gamze Ates, Charles K. Meshul, Ann Massie   +12 more
doaj   +2 more sources

X-ray computed tomography and additive manufacturing in medicine: a review [PDF]

International Journal of Metrology and Quality Engineering, 2017
The use of X-ray computed tomography (XCT) with additive manufacture (AM) within a medical context is examined in this review. The seven AM process families and various XCT scanning techniques are explained in brief, and the use of these technologies ...
Thompson Adam, McNally Donal, Maskery Ian, Leach Richard K.   +3 more
doaj   +3 more sources

NCOA4-mediated ferroptosis conducive to EMT inhibition in colorectal cancer cells was achieved through the PI3K/AKT/mTOR pathway [PDF]

Scientific Reports
The link of epithelial–mesenchymal transition (EMT) program with metastasis is well documented. However, the role of ROS in EMT process is self-contradictory.
Yun Fu, Qiufeng Zhao, Yongli Li, Yanjie Sun, Bingyu He, Cuiping Li, Wei Zhang, Yanyan Yin, Changzheng Li   +8 more
doaj   +2 more sources

Establishment of a new canine inflammatory mammary carcinoma cell line and analysis of its cystine-glutamate transporter subunit expression

Journal of Veterinary Research, 2022
Inflammatory mammary carcinoma (IMC) is a rare disease with a poor prognosis and one affecting dogs. Inflammatory breast carcinoma (IBC) is a subtype of malignant breast cancer in humans with a high degree of malignancy and a similarly poor prognosis ...
Itoh Harumichi, Naruse Ryo, Tani Kenji, Sunahara Hiroshi, Nemoto Yuki, Nakaichi Munekazu, Iseri Toshie, Horikirizono Hiro, Itamoto Kazuhito   +8 more
doaj   +1 more source

Cystine–glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice

Scientific Reports, 2021
xCT is the specific subunit of System xc-, an antiporter importing cystine while releasing glutamate. Although xCT expression has been found in the spinal cord, its expression and role after spinal cord injury (SCI) remain unknown.
Lindsay Sprimont, Pauline Janssen, Kathleen De Swert, Mathias Van Bulck, Ilse Rooman, Jacques Gilloteaux, Ann Massie, Charles Nicaise   +7 more
doaj   +1 more source

Aged xCT-Deficient Mice Are Less Susceptible for Lactacystin-, but Not 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine-, Induced Degeneration of the Nigrostriatal Pathway

Frontiers in Cellular Neuroscience, 2021
The astrocytic cystine/glutamate antiporter system xc– (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways in the brain that are dysregulated in age-related neurological ...
Eduard Bentea, Laura De Pauw, Lise Verbruggen, Lila C. Winfrey, Lauren Deneyer, Cynthia Moore, Giulia Albertini, Hideyo Sato, Ann Van Eeckhaut, Charles K. Meshul, Charles K. Meshul, Ann Massie   +11 more
doaj   +1 more source

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

Neoplasia: An International Journal for Oncology Research, 2021
Increased xCT and transsulfuration pathway has been associated with metabolic reprogramming of colorectal cancer. However, the correlation between these 2 events and the underlying molecular mechanism remains obscure.
Shanwen Chen, Dingfang Bu, Jing Zhu, Taohua Yue, Shihao Guo, Xin Wang, Yisheng Pan, Yucun Liu, Pengyuan Wang   +8 more
doaj   +1 more source

Tumor-Associated Antigen xCT and Mutant-p53 as Molecular Targets for New Combinatorial Antitumor Strategies

Cells, 2021
The cystine/glutamate antiporter xCT is a tumor-associated antigen that has been newly identified in many cancer types. By participating in glutathione biosynthesis, xCT protects cancer cells from oxidative stress conditions and ferroptosis, and ...
Jolanda Magri, Alessandro Gasparetto, Laura Conti, Enzo Calautti, Chiara Cossu, Roberto Ruiu, Giuseppina Barutello, Federica Cavallo   +7 more
doaj   +1 more source

Molecular cloning, tissue distribution and the expression of cystine/glutamate exchanger (xCT, SLC7A11) in different tissues during development in broiler chickens

Animal Nutrition, 2020
The cystine/glutamate exchanger (xCT, SLC7A11) is a component of the system Xc amino-acid antiporter that is able to export glutamate and import cysteine into cells.
Janghan Choi, Weiqi Li, Brayden Schindell, Liju Ni, Shangxi Liu, Xiaoya Zhao, Joshua Gong, Martin Nyachoti, Chengbo Yang   +8 more
doaj   +1 more source

Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway

Pharmaceutical Biology, 2022
Context The osteogenic potential of the human dental pulp stromal cells (hDPSCs) was reduced in the state of oxidative stress. Resveratrol (RSV) possesses numerous biological properties, including osteogenic potential, growth-promoting and antioxidant ...
Jingying Zhang, Rui Li, Kenny Man, Xuebin B. Yang   +3 more
doaj   +1 more source