Results 11 to 20 of about 26,824 (211)

Decreased xCT activity in patients associated with Helicobacter pylori infection

Frontiers in Pharmacology, 2022
Objective: In animals, Helicobacter pylori (Hp)-induced gastric injury is accompanied by a decrease in the activity of the cysteine/glutamate transporter (xCT), which regulates extracellular glutamate levels.
Ling Wang, Wen-Qun Li, Fen Liu, Yuan-Jian Li, Jie Du, Jie Du   +5 more
doaj   +3 more sources

xCT deficiency accelerates chemically induced tumorigenesis [PDF]

Proceedings of the National Academy of Sciences, 2010
During the course of inflammation and its resolution, macrophages are exposed to various cytotoxic materials, including reactive oxygen species. Thus, macrophages require a protective machinery against oxidative stress to survive at the inflammatory site.
Ami, Nabeyama, Ai, Kurita, Kenichi, Asano, Yasunobu, Miyake, Takuwa, Yasuda, Ikuo, Miura, Gen, Nishitai, Satoko, Arakawa, Shigeomi, Shimizu, Shigeharu, Wakana, Hisahiro, Yoshida, Masato, Tanaka   +11 more
openaire   +2 more sources

Evaluation of XCT image quality

e-Journal of Nondestructive Testing, 2023
The direct visual quality of an X-ray computed tomography (XCT) image is very subjective. Metrics to quantify the image quality have been defined for X-ray radiography, but some of these no longer seem appropriate for XCT images. This has been highlighted through an XCT interlaboratory comparison campaign, performed in the XCT working group of the ...
Anne-Françoise Obaton, Yves Gaillard, Patrick Bouvet, Olivier Guiraud, Sylvain Genot, Lionel Gay   +5 more
openaire   +1 more source

Regulation of Hippocampal Synaptic Strength by Glial xCT [PDF]

The Journal of Neuroscience, 2014
Most extracellular glutamate in the brain is released by xCT, a glial antiporter that exports glutamate and imports cystine. The function of xCT, and extracellular glutamate in general, remains unclear. Several lines of evidence suggest that glutamate from xCT could act in a paracrine fashion to suppress glutamatergic synapse strength by triggering ...
Leena E. Williams, David E. Featherstone
openaire   +2 more sources

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]

, 2017
Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac, A Castegna, A Chakrabarty, A Dasgupta, A Fogli, A Lau, A Martín, A Massie, A Massie, A Massie, A Mehta, A Prez-Samart¡n, A Tisell, A Vallejo-Illarramendi, AC Rimaniol, Ann Massie, AS Basso, Axel Methner, AY Shih, B Fogal, C Kilkenny, C Larochelle, C Matute, C Nathan, Cathy Jensen, D Bundel De, D Offen, D Piani, D Pitt, D Pitt, D Zhai, DA Baker, DA Hafler, E Merckx, EA McCullagh, Eduard Bentea, Ellen Merckx, F Loria, FN Soria, G Angelini, G Grasselli, G Sulkowski, G Sulkowski, GC Mc, Geert van Loo, Giulia Albertini, H Broholm, H Gmunder, H Hardin-Pouzet, H Sato, H Sato, H Sato, H Sato, H Sato, Hideyo Sato, I Gutcher, IE Morales Pantoja, IR Stojanovic, J Al-Omaishi, J Lewerenz, J Lewerenz, J Lewerenz, J Liefferinge Van, J Newcombe, JA Ellerhorst, Jacques De Keyser, Jan Lewerenz, JF Stover, JJ Geurts, JJ Hendriks, Joeri Van Liefferinge, K Mitosek-Szewczyk, KE Hill, KJ Smith, KS Evonuk, Lauren Deneyer, Lise Verbruggen, LM Sayre, M Kursar, M Naegele, M Ohgoh, M Penkowa, M Vercellino, Magdalena Paterka, Michael Dietrich, O Ciccarelli, O Maguire, O Pampliega, P Gadangi, P Maher, P Sarchielli, P Sarchielli, P Valk van der, P Werner, Pamela Maher, Philipp Albrecht, PW Gout, R Bridges, R Pacheco, R Srinivasan, RJ Bridges, S Bannai, S Chintala, S Licht-Mayer, T Smith, Thomas Demuyser, W Droge, Y Ganor, Y Gilgun-Sherki, Y He, Y He   +110 more
core   +2 more sources

Recent progress of amino acid transporters as a novel antitumor target

Open Chemistry, 2022
Glutamine transporters transport different amino acids for cell growth and metabolism. In tumor cells, glutamine transporters are often highly expressed and play a crucial role in their growth. By inhibiting the amino acid transport of these transporters,
Zhao Jiye, Lv Jiayi, Chen Yang, Dong Qile, Dong Hao   +4 more
doaj   +1 more source

A xCT role in tumour-associated ferroptosis shed light on novel therapeutic options

Exploration of Targeted Anti-tumor Therapy, 2022
Solute carrier family 7 member 11 (SLC7A11; also known as xCT), a key component of the cystine/glutamate antiporter, is essential for the maintenance of cellular redox status and the regulation of tumor-associated ferroptosis.
Daniela Criscuolo, Francesco Morra, Angela Celetti   +2 more
doaj   +1 more source

Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models

Journal of Experimental & Clinical Cancer Research, 2023
Background The upregulation of antioxidant mechanisms is a common occurrence in cancer cells, as they strive to maintain balanced redox state and prevent oxidative damage.
Roberto Ruiu, Chiara Cossu, Antonella Iacoviello, Laura Conti, Elisabetta Bolli, Luca Ponzone, Jolanda Magri, Alekya Rumandla, Enzo Calautti, Federica Cavallo   +9 more
doaj   +1 more source

Immunotherapy against the Cystine/Glutamate Antiporter xCT Improves the Efficacy of APR-246 in Preclinical Breast Cancer Models

Biomedicines, 2022
Breast cancer is the most frequent cancer in women. Despite recent clinical advances, new therapeutic approaches are still required. The cystine-glutamate antiporter xCT, encoded by the SLC7A11 gene, which imports cystine in exchange with glutamate, is a
Giuseppina Barutello, Antonino Di Lorenzo, Alessandro Gasparetto, Chiara Galiazzi, Elisabetta Bolli, Laura Conti, Federica Cavallo   +6 more
doaj   +1 more source

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies [PDF]

, 2019
A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the
Meierhofer, David, Xiao, Yi
core   +2 more sources