Results 201 to 210 of about 26,824 (211)
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Neuroscience Letters, 2015
Nigral cell loss in Parkinson's disease (PD) is associated with disturbed glutathione (GSH) and glutamate levels, leading to oxidative stress and excitotoxicity, respectively. System xc- is a plasma membrane antiporter that couples cystine import (amino acid that can be further used for the synthesis of GSH) with glutamate export to the extracellular ...
Eduard Bentea +6 more
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Nigral cell loss in Parkinson's disease (PD) is associated with disturbed glutathione (GSH) and glutamate levels, leading to oxidative stress and excitotoxicity, respectively. System xc- is a plasma membrane antiporter that couples cystine import (amino acid that can be further used for the synthesis of GSH) with glutamate export to the extracellular ...
Eduard Bentea +6 more
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Development of a bi-modality XCT: fDOT instrument
SPIE Proceedings, 2010We present first results of a fluorescence optical diffusion tomography experiment coupled to a X-ray computed tomography reconstruction. An instrument, dedicated to the co-registration of optical and X-ray measurements, has been developed: specific acquisition protocol and reconstruction software have been developed for carrying out fluorescence ...
Anne Koenig +6 more
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Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors
2021Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers with a dismal 5-year survival rate of 5% and very limited efficacy of the current therapeutic regimens. The lethality of PDAC stems from asymptomatic early stage of the disease, its propensity to rapidly disseminate, as well as unusual, dense and highly active ...
Milica, Vucetic +4 more
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xCT Cystine Transporter Expression in HEK293 Cells: Pharmacology and Localization
Biochemical and Biophysical Research Communications, 2001xCT, the core subunit of the system x(c)(-) high affinity cystine transporter, belongs to a superfamily of glycoprotein-associated amino acid transporters. Although xCT was shown to promote cystine transport in Xenopus oocytes, little work has been done with mammalian cells (Sato, H., Tamba, M., Ishii, T., and Bannai, S. J. Biol. Chem. 274, 11455-11458,
A Y, Shih, T H, Murphy
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Kaposi's Sarcoma-Associated Herpesvirus Fusion-Entry Receptor: Cystine Transporter xCT
Science, 2006Kaposi's sarcoma–associated herpesvirus (KSHV, human herpesvirus 8) is the causative agent of Kaposi's sarcoma and other lymphoproliferative syndromes often associated with HIV/AIDS. Functional complementary DNA selection for a receptor mediating KSHV cell fusion identified xCT, the 12-transmembrane light chain of the human cystine/
Johnan A R, Kaleeba, Edward A, Berger
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mTORC2 Regulates the Cystine–Glutamate Antiporter xCT
Cancer Discovery, 2017Abstract mTORC2 controls glutamate and glutathione metabolism in cancer cells by phosphorylating xCT.
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Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects
Cancer Research, 2017Abstract Clock genes encoding transcription factors that regulate circadian rhythms may inform chronomodulated chemotherapy, where time-dependent dose alterations might affect drug efficacy and reduce side effects. For example, inhibiting the essential cystine transporter xCT with sulfasalazine induces growth arrest in cancer cells ...
Fumiyasu, Okazaki +9 more
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Unveiling therapeutic avenues targeting xCT in head and neck cancer
Cellular OncologyHead and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies. This review examines the role of the cystine/glutamate antiporter (xCT) in HNC, specifically focusing on how xCT contributes to cancer progression through mechanisms such as redox imbalance, ferroptosis, and treatment resistance ...
Jaewang, Lee, Jong-Lyel, Roh
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