Results 31 to 40 of about 26,824 (211)

Inhibiting system xC− and glutathione biosynthesis – a potential Achilles' heel in mutant-p53 cancers

Molecular & Cellular Oncology, 2017
Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as ...
Nicholas J. Clemons, David S. Liu, Cuong P. Duong, Wayne A. Phillips   +3 more
doaj   +1 more source

Optimal co-adapted coupling for the symmetric random walk on the hypercube [PDF]

, 2008
Let X and Y be two simple symmetric continuous-time random walks on the vertices of the n-dimensional hypercube, Z2n. We consider the class of co-adapted couplings of these processes, and describe an intuitive coupling which is shown to be the fastest in
Connor, Stephen B., Jacka, Saul D.
core   +2 more sources

Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells

OncoImmunology, 2018
Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases.
Gaetano Donofrio, Giulia Tebaldi, Stefania Lanzardo, Roberto Ruiu, Elisabetta Bolli, Andrea Ballatore, Valeria Rolih, Francesca Macchi, Laura Conti, Federica Cavallo   +9 more
doaj   +1 more source

Automatic Classification of XCT Images in Manufacturing

, 2021
X-ray computed tomography (XCT) is an established non-destructive testing (NDT) method that, in combination with automatic evaluation routines, can be successfully used to establish a reliable 100% inline inspection system for defect detection of cast parts. While these systems are robust in automatically localizing suspected defects, human know-how in
Bertram Sabrowsky-Hirsch, Roxana-Maria Holom, Christian Gusenbauer, Michael Reiter, Florian Reiterer, Ricardo Fernández Gutiérrez, Josef Scharinger   +6 more
openaire   +2 more sources

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]

, 2013
Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque, A Kulak, A Wilmsmeier, B Moghaddam, B Moghaddam, B Oranje, BJ Morris, D Braff, D Lobner, D Matsuzawa, D Piani, DA Baker, DA Baker, David A. Baker, DH Ingvar, DL Braff, DV Pow, FK Graham, G Battaglia, G Franzen, G Paxinos, G Paxinos, G Rajkowska, HH Chen, J Cilia, JA Lieberman, JH Cabungcal, JI Sagara, Jon Resch, JT Coyle, K Japha, K Moussawi, K Moussawi, K Ogita, K Schwabe, K Shimosato, KE Poskanzer, KF Berman, KQ Do, Krista Qualmann, KS Kau, L Deserno, L Pasti, LA Glantz, Linghai Kong, LJ Garey, M Berk, M Berk, M Koch, M Li, M Raffa, MA Geyer, MC Angulo, ME Jackson, MJ Marino, MM Moran, NA Oberheim, NM Veelen van, NR Swerdlow, NR Swerdlow, NR Swerdlow, NR Swerdlow, O Kranich, P Bezzi, P Steullet, R Bridges, R Gysin, R Janaky, S Bannai, S Bannai, S Bannai, SG Potkin, SuJean Choi, T Majic, V Kumari, V Parpura, Victoria Lutgen, VM Goghari, VP Bakshi, WE Bunney, Y Cho, ZC Ye   +81 more
core   +2 more sources

Validation of an XCT/fDOT System on Mice [PDF]

ISRN Optics, 2012
In this paper we present systems for dual modality imaging, combining fluorescence-enhanced diffuse optical tomography and X-ray computed tomography. Fluorescence diffuse optical tomography is carried out in a cylindrical geometry, which ensures optimal sampling and a straight forward integration with the X-ray modality.
Koenig, A., Planat-Chrétien, A., Hassler, K., Bucher, M., Coutard, J.-G., Hervé, L., Brambilla, M., Josserand, V., Coll, J.-L., Vats, D., Dikaiou, K., Rudin, M., Dinten, J.-M.   +12 more
openaire   +5 more sources

xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade

Cell Death and Disease, 2022
Colorectal cancer (CRC) is one of the most commonly diagnosed and deadly malignant tumors globally, and its occurrence and progression are closely related to the poor histological features and complex molecular characteristics among patients.
Bufu Tang, Jinyu Zhu, Fangming Liu, Jiayi Ding, Yajie Wang, Shiji Fang, Liyun zheng, Rongfang Qiu, Minjiang Chen, Gaofeng Shu, Min Xu, Chenying Lu, Zhongwei Zhao, Yang Yang, Jiansong Ji   +14 more
doaj   +1 more source

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

Cell Reports, 2023
Summary: Here, we show that the tumor suppressor phosphatase and tensin homolog deleted from chromosome 10 (PTEN) sensitizes cells to ferroptosis, an iron-dependent form of cell death, by restraining the expression and activity of the cystine/glutamate ...
Kaitlyn M. Cahuzac, Abigail Lubin, Kaitlyn Bosch, Nicole Stokes, Sarah Mense Shoenfeld, Royce Zhou, Haddy Lemon, John Asara, Ramon E. Parsons   +8 more
doaj   +1 more source

Helical XCT measurement for correlative imaging

e-Journal of Nondestructive Testing, 2019
The X-ray computed tomography (XCT) is more often used to scan long objects that exceed the dimensions of the detector. Conventional scans/systems using circular trajectories touches the limits when dealing whit elongated samples. Helical scanning is a valuable solution in such a case. It enables to shorten scanning time, getting strong improvement on
Adam Břínek, Jakub Lázňovský, Tomáš Zikmund, Jakub Salplachta, Jozef Kaiser   +4 more
openaire   +1 more source

CIC reduces xCT/SLC7A11 expression and glutamate release in glioma

Acta Neuropathologica Communications, 2023
AbstractCapicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived glioma lines, RNA-sequencing and bioinformatic analysis of publicly available databases, we investigated ...
Jong-Whi Park, Omer Kilic, Minh Deo, Kevin Jimenez-Cowell, Engin Demirdizen, Hyunggee Kim, Şevin Turcan   +6 more
openaire   +3 more sources