Results 41 to 50 of about 26,824 (211)

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression

Redox Biology, 2023
Ferroptosis has emerged to be a promising approach in cancer therapies; however, colorectal cancer (CRC) is relatively insensitive to ferroptosis. Exactly how the gut microenvironment impacts the ferroptotic sensitivity of CRC remains unknown. Herein, by
Ying He, Yuhang Ling, Zhiyong Zhang, Randall Tyler Mertens, Qian Cao, Xutao Xu, Ke Guo, Qian Shi, Xilin Zhang, Lixia Huo, Kan Wang, Huihui Guo, Weiyun Shen, Manlu Shen, Wenming Feng, Peng Xiao   +15 more
doaj   +1 more source

Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Many differentiated epithelial cell types are able to reprogram in response to tissue damage. Although reprogramming represents an important physiological response to injury, the regulation of cellular plasticity is not well understood.
Anne R. Meyer, Amy C. Engevik, Spencer G. Willet, Janice A. Williams, Yong Zou, Pierre P. Massion, Jason C. Mills, Eunyoung Choi, James R. Goldenring   +8 more
doaj   +1 more source

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed

Journal of Comparative Neurology, 2015
ABSTRACTThe cystine/glutamate antiporter or system exchanges cystine for glutamate, thereby supporting intracellular glutathione synthesis and nonvesicular glutamate release. The role of system in neurological disorders can be dual and remains a matter of debate. One important reason for the contradictory findings that have been reported to date is
Van Liefferinge, Joeri, Bentea, Eduard, Demuyser, Thomas, Albertini, Giulia, Follin-Arbelet, Virginie, Holmseth, Silvia, Merckx, Ellen, Hideyo, Sato, Aerts, Joeri L, Smolders, Ilse, Arckens, Lutgarde, Danbolt, Niels C, Massie, Ann   +12 more
openaire   +3 more sources

Comparative Analysis of Internal Porosity in AM Ti64 Using X-Ray Computed Tomography and Mechanical Polishing Serial Sectioning

IEEE Open Journal of Instrumentation and Measurement
X-ray computed tomography (XCT) is a widely adopted nondestructive technique for characterizing internal porosity in additive manufactured (AM) components.
Bryce Jolley, Christine Knott, Daniel Sparkman, Michael Uchic   +3 more
doaj   +1 more source

A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo

OncoImmunology, 2018
Aggressive forms of breast cancer, such as Her2+ and triple negative breast cancer (TNBC), are enriched in breast cancer stem cells (BCSC) and have limited therapeutic options.
Elisabetta Bolli, John P. O'Rourke, Laura Conti, Stefania Lanzardo, Valeria Rolih, Jayne M. Christen, Giuseppina Barutello, Marco Forni, Federica Pericle, Federica Cavallo   +9 more
doaj   +1 more source

X-Ray Tomography To Measure Size Of Fragments From Penetration Of High-Velocity Tungsten Rods [PDF]

, 2012
Behind-armor debris that results from tungsten rods penetrating armor steel at 2 km/s was studied by analysis of recovered fragments. Fragment recovery was by means of particle board. Individual fragments were analyzed by x-ray tomography, which provides
Bless, S., Hanna, R., Levinson, S., McDonald, J., Stone, Z., Tolman, J.   +5 more
core   +1 more source

Role of SLC7A11/xCT in Ovarian Cancer

International Journal of Molecular Sciences
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance. In fact, chemoresistance weakens the therapeutic effects, worsening the outcome of this pathology.
Sonia Fantone, Federica Piani, Fabiola Olivieri, Maria Rita Rippo, Angelo Sirico, Nicoletta Di Simone, Daniela Marzioni, Giovanni Tossetta   +7 more
openaire   +3 more sources

Operando XCT with fine sampling of discharge process provides new insights into anode’s morphology evolution in a commercial zinc-air battery

Methods in Microscopy
Fine sampling of the discharge process revealed details of the anode’s morphology evolution in a commercial zinc-air battery. With special software developed for laboratory XCT scanners, it was possible to observe and quantify the evolution of individual
Dzięcioł Krzysztof, Durmus Yasin Emre, Im Eunmi, Tempel Hermann, Hausen Florian, Eichel Rüdiger-A.   +5 more
doaj   +1 more source

ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation

Cells, 2020
xCT, also known as solute carrier family 7 member 11 (SLC7A11), the light chain of the cystine/glutamate antiporter, is positively correlated with cancer progression due to antioxidant function.
Mei-Chun Chen, Li-Lin Hsu, Sheng-Fan Wang, Chih-Yi Hsu, Hsin-Chen Lee, Ling-Ming Tseng   +5 more
doaj   +1 more source

XAP5 CIRCADIAN TIMEKEEPER Affects Both DNA Damage Responses and Immune Signaling in Arabidopsis

Frontiers in Plant Science, 2021
Numerous links have been reported between immune response and DNA damage repair pathways in both plants and animals but the precise nature of the relationship between these fundamental processes is not entirely clear.
Roderick W. Kumimoto, Cory T. Ellison, Tania Y. Toruño, Aurélie Bak, Hongtao Zhang, Clare L. Casteel, Clare L. Casteel, Gitta Coaker, Stacey L. Harmer   +8 more
doaj   +1 more source