Results 1 to 10 of about 328,808 (245)

miR-1258 Attenuates Tumorigenesis Through Targeting E2F1 to Inhibit PCNA and MMP2 Transcription in Glioblastoma

Frontiers in Oncology, 2021
MicroRNAs are a group of endogenous small non-coding RNAs commonly dysregulated in tumorigenesis, including glioblastoma (GBM), the most malignant brain tumor with rapid proliferation, diffuse invasion, and therapeutic resistance.
Hongkun Qin, Yanping Gui, Rong Ma, Heng Zhang, Yabing Guo, Yuting Ye, Jia Li, Li Zhao, Yajing Wang   +8 more
doaj   +1 more source

Colonoscopy-based intramucosal transplantation of cancer cells for mouse modeling of colon cancer and lung metastasis

BioTechniques, 2021
The conventional orthotopic/xenograft models or genetically engineered murine models of colon cancer (CRC) are limited in their scope for a true understanding of tumor growth, progression and eventual metastasis in its natural microenvironment.
Rizwan Ahmad, Balawant Kumar, Raju Lama Tamang, Wei Xu, Geoffrey A Talmon, Aaron M Mohs, Punita Dhawan, Amar B Singh   +7 more
doaj   +1 more source

Replication study: androgen receptor splice variants determine taxane sensitivity in prostate cancer [PDF]

PeerJ, 2018
In 2015, as part of the Prostate Cancer Foundation–Movember Foundation Reproducibility Initiative, we published a Registered Report (Shan et al., 2015) that described how we intended to replicate selected experiments from the paper “Androgen Receptor ...
Xiaochuan Shan, Gwenn Danet-Desnoyers, Fraser Aird, Irawati Kandela, Rachel Tsui, Nicole Perfito, Elizabeth Iorns   +6 more
doaj   +2 more sources

Radius additivity score: a novel combination index for tumour growth inhibition in fixed-dose xenograft studies

Frontiers in Pharmacology, 2023
The effect of combination therapies in many cancers has often been shown to be superior to that of monotherapies. This success is commonly attributed to drug synergies.
Nicola Melillo, Jake Dickinson, Lu Tan, Hitesh B. Mistry, Hitesh B. Mistry, Heinrich J. Huber   +5 more
doaj   +1 more source

Ex Vivo Analysis of Ability of Osseodensification to Improve Dental Implant Primary Stability Using Xenograft Bone Walls

Applied Sciences, 2023
Osseodensification is a technique that involves compressing bone using specialized drilling instruments to increase bone–implant contact. The present study aimed to evaluate the structure of a xenograft bone (XB) wall created within an implantation site ...
Henrique Ferreira, Carlos Fernando Mourão, Rafael Coutinho Mello-Machado, Kayvon Javid, Rodrigo dos Santos Pereira, Plinio Mendes Senna   +5 more
doaj   +1 more source

Postoperative Study of Bone Gain in Mandibular Alveolar Bone Reconstructed with Screw-Guided Bone Regeneration Technique and Porcine-Derived Xenograft in 42 Edentulous Patient Candidates for Implant-Prosthetic Therapy

Applied Sciences, 2021
This study aimed to test whether alveolar bone gain (width and osteodensity) in mandible implant sites, augmented by the screw-guided bone regeneration (S-GBR) technique and the porcine-derived xenograft, differ from that of the mandible sites ...
Doriana Agop-Forna, Roland Törok, Bianca Törok, Raluca Dragomir, David M. Dohan Ehrenfest, Cristina Dascălu, Carmen Gabriela Stelea   +6 more
doaj   +1 more source

Inhibition of growth of colorectal cancer patient-derived subcutaneous xenografts using combined Wnt signaling pathway inhibitor and 5‑fluorouracil

Исследования и практика в медицине, 2022
Purpose of the study. Was to analyze antitumor efficacy of the XAV 939 Wnt signaling pathway inhibitor and its combination with 5 fluorouracil in subcutaneous xenografts derived from patients with colorectal cancer.Materials and methods.
A. S. Goncharova, A. V. Galina, D. V. Khodakova, G. Yu. Egorov, A. Yu. Maksimov, E. N. Kolesnikov, E. F. Komarova, A. A. Kiblitskaya, E. V. Zaikina, L. Z. Kurbanova, M. V. Mindar   +10 more
doaj   +1 more source

Engrafting Horse Immune Cells into Mouse Hosts for the Study of the Acute Equine Immune Responses

Animals, 2021
Immunological studies in the horse are frequently hampered by lack of environmental control, complicated study design, and ethical concerns when performing high risk studies.
Caroline Leeth, Janie Adkins, Alayna Hay, Sophie Bogers, Ashley Potter, Sharon Witonsky, Jing Zhu   +6 more
doaj   +1 more source

APPLICATION OF A-PRF IN AN AREA WITH NON-INTEGRATED XENOGRAFT [PDF]

Journal of IMAB, 2023
Background: Xenografts are well-studied materials that are often used in regenerative dentistry. Nowadays the number of surgeries involving bovine‑derived xenografts in implant dentistry has increased significantly.
Antoaneta Mlachkova, Zdravka Pashova-Tasseva, Hristina Maynalovska, Krassimira Gogova, Ivan Ivanov   +4 more
doaj   +1 more source

Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern. [PDF]

, 2015
Squamous cell carcinoma of the cervix, highly prevalent in the developing world, is often metastatic and treatment resistant with no standard treatment protocol.
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Mii, Sumiyuki, Miwa, Shinji, Momiyama, Masashi, Murakami, Takashi, Murata, Takuya, Tanaka, Kuniya, Uehara, Fuminari, Yamamoto, Mako, Yano, Shuya, Zhang, Nan, Zhang, Yong   +17 more
core   +6 more sources