Results 11 to 20 of about 328,808 (245)

Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

eLife, 2017
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Fung et al., 2015), that described how we intended to replicate selected experiments from the paper "Inhibition of BET recruitment to chromatin as an ...
Xiaochuan Shan, Juan Jose Fung, Alan Kosaka, Gwenn Danet-Desnoyers, Reproducibility Project: Cancer Biology   +4 more
doaj   +1 more source

Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo

Frontiers in Cell and Developmental Biology, 2023
α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative modulator of α7-nAChR produced by epithelial cells.
O. V. Shlepova, O. V. Shlepova, M. A. Shulepko, V. O. Shipunova, V. O. Shipunova, M. L. Bychkov, I. D. Kukushkin, I. D. Kukushkin, I. A. Chulina, V. N. Azev, E. I. Shramova, V. A. Kazakov, A. M. Ismailova, Y. A. Palikova, V. A. Palikov, E. A. Kalabina, E. A. Shaykhutdinova, G. A. Slashcheva, E. A. Tukhovskaya, I. A. Dyachenko, A. N. Murashev, S. M. Deyev, S. M. Deyev, S. M. Deyev, M. P. Kirpichnikov, M. P. Kirpichnikov, Z. O. Shenkarev, Z. O. Shenkarev, Z. O. Shenkarev, E. N. Lyukmanova, E. N. Lyukmanova, E. N. Lyukmanova   +31 more
doaj   +1 more source

Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

, 2018
Synovial sarcoma (SS) is a recalcitrant subgroup of soft tissue sarcoma (STS). A tumor from a patient with high grade SS from a lower extremity was grown orthotopically in the right biceps femoris muscle of nude mice to establish a patient-derived ...
Dry, Sarah M, Eckardt, Mark A, Eilber, Fritz C, Gainor, Emily, Han, Qinghong, Hayashi, Katsuhiro, Higuchi, Takashi, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kimura, Hiroaki, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Miwa, Shinji, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D, Oshiro, Hiromichi, Russell, Tara A, Singh, Arun S, Tan, Yuying, Tsuchiya, Hiroyuki, Yamamoto, Norio   +23 more
core   +2 more sources

Registered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemia

eLife, 2015
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Juan José Fung, Alan Kosaka, Xiaochuan Shan, Gwenn Danet-Desnoyers, Michael Gormally, Kate Owen, Reproducibility Project: Cancer Biology   +6 more
doaj   +1 more source

Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

, 2017
An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz, Dry, Sarah M, Eilber, Fritz C, Han, Qinghong, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Miyake, Kentaro, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Tan, Yuying, Unno, Michiaki   +15 more
core   +2 more sources

Magnetic Resonance Imaging as a Tool for Monitoring Intratibial Growth of Experimental Prostate Cancer Metastases in Mice

Methods and Protocols, 2023
Bone metastases cause morbidity and mortality in several human cancer forms. Experimental models are used to unravel the mechanisms and identify possible treatment targets. The location inside the skeleton complicates accurate assessment.
Junchi Huang, Mikael Montelius, Jan-Erik Damber, Karin Welén   +3 more
doaj   +1 more source

Establishment of Ectopic Xenografts Derived from Human Glioblastoma in Immunocompetent Mouse Model Treated with Pesticide [PDF]

Middle East Journal of Cancer, 2022
Background: In this study, we suggested an experimental procedure demonstrating the impact of pesticide on the development of ectopic xenografts of human glioblastomas in immuno-competent Balb/c mice.Method: In this in-vivo study, the mice were treated ...
Abderrezak Ghidouche, Souhil Tliba, Djida Ait-Ali   +2 more
doaj   +1 more source

Single tumor imaging with multiple antibodies targeting different antigens

BioTechniques, 2012
Antibodies are important drugs for treating cancer and there is strong rationale for using multiple antibodies to improve outcomes. We labeled two breast cancer binding antibodies, anti-ErbB2 and anti-EpCAM, with infrared fluorescence dyes of different ...
Yujing Sun, Girja Shukla, Stephanie C. Pero, Erika Currier, Giselle Sholler, David Krag   +5 more
doaj   +1 more source

Next-generation transcatheter aortic valve implantationCentral MessagePerspective

JTCVS Open, 2020
Objective: Transcatheter aortic valve implantation (TAVI) procedures are increasing rapidly, but the durability of tissue valve and periprocedural complications are not satisfactory.
Hong-Gook Lim, MD, PhD, Saeromi Jeong, MS, Gi Beom Kim, MD, PhD, Whal Lee, MD, PhD, Kuk Hui Son, MD, PhD, Yong Jin Kim, MD, PhD   +5 more
doaj   +1 more source

The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing's sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy. [PDF]

, 2017
The aim of the present study was to determine the usefulness of a patient-derived orthotopic xenograft (PDOX) nude-mouse model of a doxorubicin-resistant metastatic Ewing's sarcoma, with a unique combination of a FUS-ERG fusion and CDKN2A deletion, to ...
Bouvet, Michael, Chishima, Takashi, Dry, Sarah M, Eckardt, Mark A, Eilber, Fritz C, Elliott, Irmina A, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Matsuyama, Ryusei, Miyake, Kentaro, Miyake, Masuyo, Momiyama, Masashi, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Singh, Arun S   +20 more
core   +1 more source