Results 11 to 20 of about 53,515 (304)

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans[S]

Journal of Lipid Research, 2014
While genetic determinants strongly influence HDL cholesterol (HDLc) levels, most genetic causes underlying variation in HDLc remain unknown. We aimed to identify novel rare mutations with large effects in candidate genes contributing to extreme HDLc in ...
Roshni R. Singaraja, Ian Tietjen, G. Kees Hovingh, Patrick L. Franchini, Chris Radomski, Kenny Wong, Margaret vanHeek, Ioannis M. Stylianou, Linus Lin, Liangsu Wang, Lyndon Mitnaul, Brian Hubbard, Michael Winther, Maryanne Mattice, Annick Legendre, Robin Sherrington, John J. Kastelein, Karen Akinsanya, Andrew Plump, Michael R. Hayden   +19 more
doaj   +1 more source

Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?

Neurotrauma Reports, 2022
Traumatic brain injury (TBI) is associated with high mortality and morbidity in children and adults. Unfortunately, there is no effective management for TBI in the acute setting.
Misun Hwang, Rajarshi Chattaraj, Anush Sridharan, Samuel S. Shin, Angela N. Viaene, Sophie Haddad, Dmitry Khrichenko, Chandra Sehgal, Daeyeon Lee, Todd J. Kilbaugh   +9 more
doaj   +1 more source

Xenon Exerts Neuroprotective Effects on Kainic Acid-Induced Acute Generalized Seizures in Rats via Increased Autophagy

Frontiers in Cellular Neuroscience, 2020
Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals.
Wei Zhu, Jianguo Zhu, Shengfa Zhao, Jieqing Li, Dianjun Hou, Yurong Zhang, Hongliu Sun   +6 more
doaj   +1 more source

Combined Xenon and Epidural Anesthesia During Surgical Correction of Joint Deformities in the Lower Extremities of Children with Cerebral Palsy

Общая реаниматология, 2020
Objectives. The objective of this study is to compare different methods of combination general and regional anesthesia based on xenon.Materials and methods.
E. A. Adkina, V. L. Ayzenberg, E. S. Iakovleva, O. N. Gudilina, A. V. Diordiev   +4 more
doaj   +1 more source

Xenon-inhibition of the MscL mechano-sensitive channel and the CopB copper ATPase under different conditions suggests direct effects on these proteins. [PDF]

PLoS ONE, 2018
Xenon is frequently used as a general anesthetic in humans, but the mechanism remains an issue of debate. While for some membrane proteins, a direct interaction of xenon with the protein has been shown to be the inhibitory mechanism, other membrane ...
Evgeny Petrov, Gopalakrishnan Menon, Paul R Rohde, Andrew R Battle, Boris Martinac, Marc Solioz   +5 more
doaj   +1 more source

Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial

Critical Care Explorations, 2021
OBJECTIVES:. This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest. DESIGN:.
Antti Saraste, MD, PhD, Haitham Ballo, MD, Olli Arola, MD, PhD, Ruut Laitio, MD, PhD, Juhani Airaksinen, MD, PhD, Marja Hynninen, MD, PhD, Minna Bäcklund, MD, PhD, Emmi Ylikoski, MD, PhD, Johanna Wennervirta, MD, PhD, Mikko Pietilä, MD, PhD, Risto O. Roine, MD, PhD, Veli-Pekka Harjola, MD, PhD, Jussi Niiranen, MD, PhD, Kirsi Korpi, MD, PhD, Marjut Varpula, MD, PhD, Harry Scheinin, MD, PhD, Mervyn Maze, MB ChB, Tero Vahlberg, MSc, Timo Laitio, MD, PhD, for the Xe-HYPOTHECA Study Group, Sami Virtanen, Riitta Parkkola, Jani Saunavaara, Juha Martola, Heli Silvennoinen, Marjaana Tiainen, Juha Grönlund, Outi Inkinen, Päivi Silvasti, Eija Nukarinen, Klaus T. Olkkola   +30 more
doaj   +1 more source

Nausea and Vomiting following Balanced Xenon Anesthesia Compared to Sevoflurane: A Post-Hoc Explorative Analysis of a Randomized Controlled Trial. [PDF]

PLoS ONE, 2016
Like other inhalational anesthetics xenon seems to be associated with post-operative nausea and vomiting (PONV). We assessed nausea incidence following balanced xenon anesthesia compared to sevoflurane, and dexamethasone for its prophylaxis in a ...
Astrid V Fahlenkamp, Christian Stoppe, Jan Cremer, Ingeborg A Biener, Dirk Peters, Ricarda Leuchter, Albrecht Eisert, Christian C Apfel, Rolf Rossaint, Mark Coburn   +9 more
doaj   +1 more source

Effect of xenon-oxygen inhalations on functional status of cardiovascular system in oncological patients suffering chronic pain syndrome

Исследования и практика в медицине, 2022
Purpose of the study. Assessment of xenon-oxygen inhalations effect on functional status of cardiovascular system in oncological patients with chronic pain syndrome.Materials and methods.
V. I. Potievskaya, G. R. Abuzarova, R. R. Sarmanaeva, A. V. Loboda, M. B. Potievskiy, S. V. Kuznetsov, A. D. Kaprin   +6 more
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Closed circuit xenon delivery for 72h in neonatal piglets following hypoxic insult using an ambient pressure automated control system: Development, technical evaluation and pulmonary effects.

PLoS ONE, 2020
BackgroundTherapeutic hypothermia (TH) for 72h is the standard treatment following neonatal encephalopathy (NE). However, one-third do not benefit and adjunctive therapies are urgently needed.
John Dingley, Satomi Okano, Richard Lee-Kelland, Emma Scull-Brown, Marianne Thoresen, Ela Chakkarapani   +5 more
doaj   +1 more source

Mode-Dependent Effect of Xenon Inhalation on Kainic Acid-Induced Status Epilepticus in Rats

Frontiers in Cellular Neuroscience, 2019
Previous studies have reported the possible neuroprotective effects of xenon treatment. The purpose of this study was to define the range of effective xenon ratio, most effective xenon ratio, and time-window for intervention in the kainic acid (KA ...
Yurong Zhang, Mengdi Zhang, Jie Yu, Wei Zhu, Qiaoyun Wang, Xiaohong Pan, Xue Gao, Jing Yang, Hongliu Sun   +8 more
doaj   +1 more source