Results 171 to 180 of about 157,699 (364)

Fluoxetine Treatment in Epilepsy of Infancy with Migrating Focal Seizures Due to KCNT1 Variants: An Open Label Study

open access: yesAnnals of Neurology, Volume 98, Issue 1, Page 48-61, July 2025.
Objective Gain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy.
Marina Trivisano   +13 more
wiley   +1 more source

Spiral waves speed up cell cycle oscillations in the frog cytoplasm [PDF]

open access: yesarXiv
Spiral waves are a well-known phenomenon in excitable media, playing critical roles in biological systems such as cardiac tissues, where they are involved in arrhythmias, and in slime molds, where they guide collective cell migration. However, their presence in the cytoplasm of cells has not been reported to date.
arxiv  

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

Adaptations of the Vertebrate Retina to Low‐Light Conditions: A Review

open access: yesAnatomia, Histologia, Embryologia, Volume 54, Issue 4, July 2025.
ABSTRACT Vision is a critical sensory modality in vertebrates, enabling diverse adaptations to environmental challenges. This review explores the remarkable adaptations of vertebrate eyes to low‐light environments, such as nocturnal habitats, deep‐sea ecosystems and subterranean niches.
R. Cobo   +3 more
wiley   +1 more source

Tissue-Specific Gene Inactivation in Xenopus laevis: Knockout of lhx1 in the Kidney with CRISPR/Cas9

open access: yesGenetics, 2017
B. DeLay   +8 more
semanticscholar   +1 more source

Rescue of loss‐of‐function long QT syndrome‐associated mutations in KV7.1/KCNE1 by the endocannabinoid N‐arachidonoyl‐L‐serine (ARA‐S)

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 13, Page 2861-2877, July 2025.
Abstract Background and Purpose Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in the genes encoding KV7.1/KCNE1 are the most frequent, with channel loss‐of‐function contributing to LQTS.
Irene Hiniesto‐Iñigo   +11 more
wiley   +1 more source

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