Results 31 to 40 of about 842 (148)

Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering**

Angewandte Chemie International Edition, Volume 62, Issue 2, January 9, 2023., 2023
Structural evaluation of the Bam complex with darobactin 9 using cryo‐EM combined with bioactivity evaluation led to biosynthetic engineering of novel derivatives with enhanced activity against Gram‐negative pathogens, including clinically relevant isolates.
Carsten E. Seyfert, Christoph Porten, Biao Yuan, Selina Deckarm, Fabian Panter, Chantal D. Bader, Janetta Coetzee, Felix Deschner, Kamaleddin H. M. E. Tehrani, Paul G. Higgins, Harald Seifert, Thomas C. Marlovits, Jennifer Herrmann, Rolf Müller   +13 more
wiley   +1 more source

A Surface Exposed, Two-Domain Lipoprotein Cargo of a Type XI Secretion System Promotes Colonization of Host Intestinal Epithelia Expressing Glycans

Frontiers in Microbiology, 2022
The only known required component of the newly described Type XI secretion system (TXISS) is an outer membrane protein (OMP) of the DUF560 family. TXISSOMPs are broadly distributed across proteobacteria, but properties of the cargo proteins they secrete ...
Alex S. Grossman, Cristian A. Escobar, Erin J. Mans, Nicholas C. Mucci, Terra J. Mauer, Katarina A. Jones, Cameron C. Moore, Paul E. Abraham, Robert L. Hettich, Liesel Schneider, Shawn R. Campagna, Shawn R. Campagna, Shawn R. Campagna, Katrina T. Forest, Heidi Goodrich-Blair, Heidi Goodrich-Blair   +15 more
doaj   +1 more source

Identification and Functional Characterization of a Xenorhabdus nematophila Oligopeptide Permease [PDF]

Applied and Environmental Microbiology, 2004
ABSTRACT The bacterium Xenorhabdus nematophila is a mutualist of Steinernema carpocapsae nematodes and a pathogen of insects. Presently, it is not known what nutrients the bacterium uses to thrive in these host environments.
Samantha S, Orchard, Heidi, Goodrich-Blair   +1 more
openaire   +2 more sources

Involvement of a novel Pseudomonas protegens strain associated with entomopathogenic nematode infective juveniles in insect pathogenesis

Pest Management Science, Volume 78, Issue 12, Page 5437-5443, December 2022., 2022
A novel strain of Pseudomonas protegens was found to be stably associated with the soil‐dwelling entomopathogenic nematode Steinernema feltiae. This noncore bacterium can act as a stand‐alone bioinsecticide or may take advantage of the vector nematode to reach the insect haemocoeal where it can proliferate.
Luca Ruiu, Maria Giovanna Marche, Maria Elena Mura, Eustachio Tarasco   +3 more
wiley   +1 more source

Detection of Quorum Sensing Signals in Gram-Negative Bacteria by Using Reporter Strain CV026

Notulae Scientia Biologicae, 2010
Quorum sensing signals are referred to as acylated homoserine lactones (AHL) that are mainly found in Gram-negative bacteria. It implies the ability of certain bacteria of producing different AHL molecules.
Ahmad Humayan KABIR, Anindya GHOSH ROY, Mohammad FIROZ ALAM, Rafiul ISLAM   +3 more
doaj   +3 more sources

Production and characterization of anti-bacterial metabolite(s) from Egyptian archaeological sites. [PDF]

Sci Rep
Antimicrobial agents produced by Xenorhabdus spp. may hold the answer to novel antimicrobial agents. Antibacterial activity of some bacterial strains isolated from different Egyptian archaeological sites was evaluated.
Youssef AA, Elwakil BH, Ghareeb DA, Olama ZA.   +3 more
europepmc   +2 more sources

Analysis of the PixA Inclusion Body Protein of Xenorhabdus nematophila [PDF]

Journal of Bacteriology, 2006
ABSTRACT The symbiotic pathogenic bacterium Xenorhabdus nematophila produces two distinct intracellular inclusion bodies. The pixA gene, which encodes the 185-residue methionine-rich PixA inclusion body protein, was analyzed in the present study.
M, Goetsch, H, Owen, B, Goldman, S, Forst   +3 more
openaire   +2 more sources

Type S Non‐Ribosomal Peptide Synthetases for the Rapid Generation of Tailormade Peptide Libraries**

Chemistry – A European Journal, Volume 28, Issue 26, May 6, 2022., 2022
Following a previously published proof‐of‐principle study on generating bipartite type S non‐ribosomal peptide synthetases (NRPSs), the de novo generation of non‐ribosomal peptide libraries with unprecedented simplicity was envisaged. By using synthetic zippers, NRPSs were split in up to three subunits to produce 49 peptides at titres up to 145 mg L−1.
Nadya Abbood, Tien Duy Vo, Jonas Watzel, Kenan A. J. Bozhueyuek, Helge B. Bode   +4 more
wiley   +1 more source

Protein with negative surface charge distribution, Bnr1, shows characteristics of a DNA‐mimic protein and may be involved in the adaptation of Burkholderia cenocepacia

MicrobiologyOpen, Volume 11, Issue 1, February 2022., 2022
Burkholderia negatively surface‐charged regulatory protein 1 (Bnr1) is an acidic protein expressed by Burkholderia cenocepacia that is upregulated in the stationary phase; in response to low oxygen stress; or the hypoxic environment of the chronically infected cystic fibrosis lung. It possesses a negatively charged surface and its deletion dramatically
Ruth Dennehy, Niamh Duggan, Simon Dignam, Sarah McCormack, Eugene Dillon, Jessica Molony, Maria Romano, Yueran Hou, Laura Ardill, Matthew V. X. Whelan, Zuzanna Drulis‐Kawa, Tadhg Ó'Cróinín, Miguel A. Valvano, Rita Berisio, Siobhán McClean   +14 more
wiley   +1 more source

Physiological Constants of the Entomopathogenic Bacterium Xenorhabdus nematophila Determined by Microbial Growth Kinetics. [PDF]

ISRN Microbiol, 2014
Xenorhabdus nematophila, an entomopathogenic bacterium that symbiotically associates with the entomoparasitic nematode Steinernema carpocapsae, was studied to determine its physiological parameters of glucose utilization. X. nematophila was cultured in chemically defined media containing various concentrations of glucose under optimal conditions ...
Kooliyottil R, Inman F, Mandjiny S, Holmes L.   +3 more
europepmc   +4 more sources