Results 91 to 100 of about 46,793 (276)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Local critical behaviour at aperiodic surface extended perturbation in the Ising quantum chain

, 1994
The surface critical behaviour of the semi--infinite one--dimensional quantum Ising model in a transverse field is studied in the presence of an aperiodic surface extended modulation.
Benza G V, Ceccato H A, D Karevski, Dekking M, Dumont J M, G Palagyi, Godrèche C, Grimm U, Harris AB, Henkel M, Iglói, Iglói F, Iglói F, Iglói F, Iglói F, Jordan P, L Urban, Langie G, Lieb E H, Lin Z, Luck J M, Luck J M, Okabe Y, Okabe Y, Pfeuty P, Queffélec M, Sakamoto S, Tracy C A, Turban L, Turban L   +29 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Scientific Opportunities for Heterogeneous Catalysis Research at the SuperXAS and SNBL Beam Lines

CHIMIA, 2012
In this short review, we describe the complementary experimental capabilities for catalysis research at two beam lines available to the Swiss community, SuperXAS at SLS (Swiss Light Source, Villigen) and SNBL (Swiss Norwegian Beam lines) at ESRF
Paula M. Abdala, Olga V. Safonova, Geir Wiker, Wouter van Beek, Herman Emerich, Jeroen A. van Bokhoven, Jacinto Sá, Jakub Szlachetko, Maarten Nachtegaal   +8 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Parsing Large XES Files for Discovering Process Models: A Big Data Problem [PDF]

, 2015
Process mining is a group of techniques for retrieving de-facto models using system traces. Discovering algorithms can obtain mathematical models exploiting the information contained into list of events of activities.
Aponte Báez, Yosvanys, Marco Such, Manuel, Sánchez, Alexander   +2 more
core   +1 more source

New spectroscopic results in Xe II, Xe III, and Xe IV

, 1982
Nuevos resultados obtenidos en el espectro del xenon espontaneo logrado mediante la utilizacion de un tuba de laser gaseoso pulsarlo convencional coma fuente de luz son presentados en este trabajo. Han sido estudiadas en total 626 I ineas espectrales las que fueron asignadas ionicamente de la siguiente manera: 50 al espectro del Xe II, 103 al de Xe Ill
Reyna Almandos, Jorge Guillermo, Gallardo, Mario, Garavaglia, Mario J.   +2 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Complex Formation and Liquid-Liquid Extraction in the Niobium(V) – 2,4-Dihydroxythiophenol– Hydrophobic Amines System [PDF]

Pakistan Journal of Analytical & Environmental Chemistry, 2015
The formation and solvent extraction of new ion-association com¬ple- ¬xes between anionic chelat of niobium(V) with 2,4-dihydroxy¬thio¬phenol (DHTP) and hydrophobic amines (HAs). The HAs were aniline (An), N-methyl¬aniline (MAn), N,N-dimethylaniline
ALI Z. ZALOV
doaj