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XIAP’s Profile in Human Cancer
Biomolecules, 2020 XIAP, the X-linked inhibitor of apoptosis protein, regulates cell death signaling pathways through binding and inhibiting caspases. Mounting experimental research associated with XIAP has shown it to be a master regulator of cell death not only in ...
Huailu Tu, Max Costa
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Molecular Cancer, 2006 Background Apoptosis resistance occurs in various tumors. The anti-apoptotic XIAP protein is responsible for inhibiting apoptosis by reducing caspase-3 activation.
Bart Spee
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Journal of Hematology and Oncology, 2017 Background The X-linked inhibitor of apoptosis protein (XIAP) is a well-known potent apoptosis suppressor and also participates in cancer cell biological behaviors, therefore attracting great attentions as a potential antineoplastic therapeutic target ...
Chao Huang, Guosong Jiang, Honglei Jin
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Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis
EBioMedicine, 2017 The emerging regulatory role of deubiquitinases (DUBs) has been implicated in various fundamental processes and pathogenesis. To determine the pivotal role that DUBs play in mediating tumorigenesis, we have performed a non-biased screen of 67 human DUBs ...
Zhuan Zhou, Qingyu Luo, Yi Huang
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XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1 [PDF]
Cell Death and DiseaseX-linked inhibitor of apoptosis protein (XIAP), a member of the IAP family, is overexpressed in a variety of tumors and plays an important role in tumor progression.
Ning Sun +15 more
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PIM2 promotes lung adenocarcinoma cell migration by regulating XIAP/NF-𝜿B pathway [PDF]
Journal of Men's Health, 2021 Background and objective: Proviral insertion site in Moloney murine leukemia virus (PIM)2 functions as a serine/threonine kinase to participate in regulating cell proliferation and cell cycle. PIM2 has been shown to be elevated in the lung cancer cell
Yanling Gai +2 more
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Melatonin increases 5-flurouracil-mediated apoptosis of colorectal cancer cells through enhancing oxidative stress and downregulating survivin and XIAP [PDF]
BioImpacts, 2021 Introduction: Colorectal cancer (CRC) is one of the most lethal human malignancies with a global alarming rate of incidence. The development of resistance against common chemotherapeutics such as 5-fluorouracil (5-FU) remains a big burden for CRC therapy.
Ainaz Mihanfar +5 more
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陆军军医大学学报, 2022 Objective To investigate mechanism and effect on (-)-gossypol enhancing epirubicin killing hepatocellular carcinoma (HCC) cells. Methods HCC cells (Hep 3B and HuH7) were divided into 8 groups: control, (-)-gossypol, epirubicin, combination, si-control ...
JIANG Wenbin +3 more
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Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMAC
Cells, 2020 Inhibitors of apoptosis (IAPs) are a family of proteins that regulate cell death and inflammation. XIAP (X-linked IAP) is the only family member that suppresses apoptosis by directly binding to and inhibiting caspases.
Ruqaia Abbas, Sarit Larisch
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E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity. [PDF]
PLoS ONE, 2012 Although an increased expression level of XIAP is associated with cancer cell metastasis, the underlying molecular mechanisms remain largely unexplored.
Jinyi Liu +9 more
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