Results 131 to 140 of about 17,869 (171)

Blocking XIAP:CASP7-p19 selectively induces apoptosis of CASP3/DR malignancies by a novel reversible small molecule. [PDF]

Cell Death Dis
Chen SH, Wu SY, Chang YX, Lui EN, Chang CK, Lin SW, Hsiao M, Yang JM, Liang PH.   +8 more
europepmc   +1 more source

Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications. [PDF]

Mol Med
Ghorbanpour A, Rohani P, Shahrokh S, Dimitrov G, Totonchi M, Dimitrov S.   +5 more
europepmc   +1 more source

Late presentation of X-linked inhibitor of apoptosis (XIAP) deficiency in a young adult. [PDF]

Allergy Asthma Clin Immunol
Nazarali S, Derfalvi B, Clark P.
europepmc   +1 more source

LncRNA SNHG4 Regulates Lipid Metabolism and Inflammation in Non-Alcoholic Fatty Liver Disease by Targeting miR-34b-5p/XIAP Axis. [PDF]

Turk J Gastroenterol
Ding Y, Zheng S, Fu XN, Ma C, Juan Y.
europepmc   +1 more source

A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma. [PDF]

Front Cell Dev Biol
Wang Y, Li X, Dong X, Yuan H, Fang R, Zhang R, Wang WJ.   +6 more
europepmc   +1 more source

Targeted therapies and their outcomes in monogenic very early onset inflammatory bowel disease: a systematic review. [PDF]

BMC Gastroenterol
Abhari AP, Rezvanian P, Sohrabi E, Hosseini K, Attauabi M, Gupta R, Najafi K.   +6 more
europepmc   +1 more source

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XIAP, the guardian angel

Nature Reviews Molecular Cell Biology, 2001
Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival. One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation.
Martin Holcik, Robert G Korneluk
exaly   +3 more sources

Quercetin ameliorates XIAP deficiency–associated hyperinflammation

Blood, 2022
Abstract XIAP (X-linked inhibitor of apoptosis) deficiency is a rare inborn error of immunity. XIAP deficiency causes hyperinflammatory disease manifestations due to dysregulated TNF (tumor necrosis factor)-receptor signaling and NLRP3 (NOD- [nucleotide-binding oligomerization domain], LRR- [leucine-rich repeat] and pyrin domain ...
Samuel C C, Chiang, Erika, Owsley, Neelam, Panchal, Vijaya, Chaturvedi, Catherine E, Terrell, Michael B, Jordan, Parinda A, Mehta, Stella M, Davies, Nagako, Akeno, Claire, Booth, Rebecca A, Marsh   +10 more
openaire   +2 more sources

XIAP deficiency syndrome in humans

Seminars in Cell and Developmental Biology, 2015
The X-linked inhibitor of apoptosis (XIAP) deficiency, also known as the X-linked lymphoproliferative syndrome type 2 (XLP-2), is a rare primary immunodeficiency. XIAP deficiency is characterized by a key triad of clinical manisfestations, which consist of a high susceptibility to develop hemophagocytic lymphohistiocytosis (HLH) frequently triggered by
Sylvain Latour, Claire Aguilar
exaly   +3 more sources