Results 141 to 150 of about 17,869 (171)

Competing for XIAP

Nature Reviews Molecular Cell Biology, 2001
exaly   +2 more sources

Immunohistochemical detection of XIAP in melanoma

Journal of Cutaneous Pathology, 2007
Background:  The X‐linked inhibitor of apoptosis protein (XIAP) is the most potent of the inhibitor of apoptosis family of eight proteins. High levels of XIAP have been found in melanoma cell lines and are believed to play a role in therapeutic resistance in a number of malignancies.
Patrick O M, Emanuel, Robert G, Phelps, Adarsh, Mudgil, Michail, Shafir, David E, Burstein   +4 more
openaire   +2 more sources

Non-peptidic small molecule inhibitors of XIAP

Bioorganic & Medicinal Chemistry Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Park, Cheol-Min, Sun, CH, Olejniczak, ET, Wilson, AE, Meadows, RP, Betz, SF, Elmore, SW, Fesik, SW   +7 more
openaire   +3 more sources

Targeting XIAP for the treatment of malignancy [PDF]

Cell Death and Differentiation, 2005
X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family of caspase inhibitors that selectively binds and inhibits caspases-3, -7 and -9, but not caspase-8. As such, XIAP blocks a substantial portion of the apoptosis pathway and is an attractive target for novel therapeutic agents for the treatment of ...
A D, Schimmer, S, Dalili, R A, Batey, S J, Riedl   +3 more
exaly   +3 more sources

XIAP: Apoptotic brake and promising therapeutic target

Apoptosis, 2001
The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the newly discovered family of intrinsic inhibitors of apoptosis (IAP) proteins. IAPs block cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. Although other proteins have been identified which inhibit upstream caspases, only the IAPs have been demonstrated to
M, Holcik, H, Gibson, R G, Korneluk
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cIAPs and XIAP reduce RIPKs to silence

Blood, 2014
In this issue of Blood , Wong et al emphasize the implication of cellular and X-linked inhibitors of apoptosis (cIAP1, cIAP2, and XIAP) in the regulation of myeloid cell homeostasis through the inhibition of receptor-interacting protein kinase (RIPK1 and RIPK3)–dependent cytokine production ...
Arnaud Jacquel, Patrick Auberger
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SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis

Pediatrics International, 2012
AbstractHemophagocytic lymphohistiocytosis (HLH) is a multisystem inflammatory disorder due to cytokine overproduction from excessively activated lymphocytes and macrophages. HLH has been divided into two subgroups: primary HLH and secondary HLH.
Xi, Yang, Toshio, Miyawaki, Hirokazu, Kanegane   +2 more
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Transient pockets on XIAP-BIR2: toward the characterization of putative binding sites of small-molecule XIAP inhibitors

Journal of Molecular Modeling, 2011
Protein-protein interactions are abundant in signal transduction pathways and thus of crucial importance in the regulation of apoptosis. However, designing small-molecule inhibitors for these potential drug targets is very challenging as such proteins often lack well-defined binding pockets. An example for such an interaction is the binding of the anti-
Susanne, Eyrisch, Jose L, Medina-Franco, Volkhard, Helms   +2 more
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Maternal Gonosomal Mosaicism Causes XIAP Deficiency

Journal of Clinical Immunology, 2022
Dan Tomomasa, Motoi Yamashita, Takahiro Kamiya, Tomohiro Morio, Hirokazu Kanegane   +4 more
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XiAP-ping Castration-Resistant Prostate Cancer

Science Translational Medicine, 2013
The XAF1-XIAP pathway provides a mechanistic link and a path for personalized prostate cancer therapy.
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