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S-nitrosylation of XIAP at Cys213 of BIR2 domain impairs XIAP's anti-caspase-3 activity
2014XIAP is the most widely expressed IAP and plays an important role in regulating cell survival. XIAP contains three baculoviral IAP repeats (BIRs) domain and a RING domain. BIR domains provide XIAP anticaspase activities whereas RING functions as an E3 ligase. S-nitrosylation is a reversible post-translational modification of proteins by adding a nitric
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Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment
Cancer Cell, 2016Sheng Zhou, Yuhong Du, Jing Xiong
exaly
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
Cancer Cell, 2004Guy S Salvesen
exaly
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Molecular Cell, 2018surinder Jeet +2 more
exaly