Results 11 to 20 of about 17,869 (171)
PLoS ONE, 2017 Long noncoding RNAs (lncRNAs) play roles in the tumorigenesis, proliferation and metastasis of tumor cells. Previous studies indicate that the transcription factor Sp1 is responsible for transcription of the XIAP gene, but it is unknown whether lncRNAs ...
Jun Cai +5 more
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MedComm – OncologyX‐linked inhibitor of apoptosis protein (XIAP) is a multifunctional protein that regulates many cellular functions. Anoikis resistance is necessary for hepatocellular carcinoma (HCC) intrahepatic spread and extrahepatic metastasis.
Qingyu Zeng +11 more
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XIAP Regulates Caspase Activity in Degenerating Axons
Cell Reports, 2013 Our knowledge of the destructive events that regulate axonal degeneration is rudimentary. Here, we examine the role of caspases and their endogenous inhibitor, the X-linked inhibitor of apoptosis protein (XIAP), in axonal degeneration of dorsal root ...
Nicolas Unsain +4 more
doaj +3 more sources
Evolution of Our Understanding of XIAP Deficiency [PDF]
Frontiers in Pediatrics, 2021 X-linked inhibitor of apoptosis (XIAP) deficiency is a rare inborn error of immunity first described in 2006. XIAP deficiency is characterised by immune dysregulation and a broad spectrum of clinical manifestations, including haemophagocytic ...
Anne C. A. Mudde +4 more
doaj +4 more sources
Sex-Specific Factors Influencing HIV Infection. [PDF]
Immunol RevABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Pujantell M, Altfeld M.
europepmc +2 more sources
XIAP inhibits autophagy via XIAP‐Mdm2‐p53 signalling [PDF]
The EMBO Journal, 2013 The primary role of autophagy is adaption to starvation. However, increasing evidence suggests that autophagy inhibition also plays an important role in tumorigenesis. Upregulation of X-linked inhibitor of apoptosis (XIAP) has been associated to a variety of human cancers, yet the underlying mechanisms remain obscure.
Xing, Huang +3 more
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Cell & Bioscience, 2020 Background The X-linked inhibitor of apoptosis protein (XIAP) is the most potent caspase inhibitor of the IAP family in apoptosis pathway. This study aims to identify the molecular targets of XIAP in human breast cancer cells exposed to XIAP siRNA by ...
Mehdi Agha Gholizadeh +5 more
doaj +1 more source
Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase
Scientific Reports, 2022 The product encoded by the X-linked inhibitor of apoptosis (XIAP) gene is a multi-functional protein which not only controls caspase-dependent cell death, but also participates in inflammatory signalling, copper homeostasis, response to hypoxia and ...
Lauren G. Russell +4 more
doaj +1 more source
XIAP: inhibitor of two worlds [PDF]
The EMBO Journal, 2013 Autophagy is a catabolic mechanism that selectively eliminates long-lived proteins, aggregates and damaged organelles and is thereby fundamental in maintaining cellular homeostasis. As a prosurvival mechanism, autophagy is carefully regulated and its dysfunction is associated with cancer development. Work of Huang et al (2013) in this issue of The EMBO
Merlo, P, CECCONI, FRANCESCO
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Characterization of XIAP-Deficient Mice [PDF]
Molecular and Cellular Biology, 2001 The inhibitor of apoptosis protein (IAP) family consists of a number of evolutionarily conserved proteins that function to inhibit programmed cell death. X-linked IAP (XIAP) was cloned due to its sequence homology with other family members and has previously been shown to prevent apoptosis by binding to active caspases 3, 7, and 9 in vitro.
H, Harlin +4 more
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