Results 21 to 30 of about 17,869 (171)

X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia–ischemia

Neurobiology of Disease, 2004
Nine-day-old transgenic XIAP overexpressing (TG-XIAP) and wild-type mice were subjected to left carotid artery ligation and 10% O2 for 60 min, leading to widespread infarctions in the ipsilateral hemisphere during reperfusion. The activation of caspase-3
Xiaoyang Wang, Changlian Zhu, Xinhua Wang, Henrik Hagberg, Laura Korhonen, Mats Sandberg, Dan Lindholm, Klas Blomgren   +7 more
doaj   +1 more source

RIPK2 NODs to XIAP and IBD

Seminars in Cell & Developmental Biology, 2021
The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders.
Topal, Y, Gyrd-Hansen, M
openaire   +3 more sources

Impact of XIAP protein levels on the survival of myeloma cells

Haematologica, 2009
Background XIAP is the best characterized and the most potent direct endogenous caspase inhibitor and is considered a key actor in the control of apoptotic threshold in cancer cells.
Grégoire Desplanques, Nicola Giuliani, Roberto Delsignore, Vittorio Rizzoli, Régis Bataille, Sophie Barillé-Nion   +5 more
doaj   +1 more source

XIAP is a predictor of cisplatin-based chemotherapy response and prognosis for patients with advanced head and neck cancer. [PDF]

PLoS ONE, 2012
BACKGROUND: Approximately 60-80% of patients with advanced head and neck squamous cell carcinoma (HNSCC) die within five years after diagnosis. Cisplatin-based chemotherapy is the most commonly used palliative treatment for these patients.
Xi-Hu Yang, Zhi-En Feng, Ming Yan, Sayaka Hanada, Hui Zuo, Cheng-Zhe Yang, Ze-Guan Han, Wei Guo, Wan-Tao Chen, Ping Zhang   +9 more
doaj   +1 more source

Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP)

FEBS Open Bio, 2014
Defects in the regulation of apoptosis are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as the X-linked inhibitor of apoptosis protein (XIAP).
Maximilian A. Seiter, Stefan Salcher, Martina Rupp, Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Jérémie Mortier, Gerhard Wolber, Judith M. Rollinger, Petra Obexer, Michael J. Ausserlechner   +9 more
doaj   +1 more source

Identification of an Xiap-like pseudogene on mouse chromosome 7. [PDF]

PLoS ONE, 2009
The most thoroughly characterized mammalian IAP is XIAP/BIRC4, which can inhibit caspases 9, 3 and 7, but may also regulate apoptosis through interactions with other proteins such as Smac/DIABLO, HtrA2/Omi, XAF1, TAK1, cIAP1, and cIAP2.High throughput ...
Aneta Kotevski, Wendy D Cook, David L Vaux, Bernard A Callus   +3 more
doaj   +1 more source

Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association.

PLoS ONE, 2011
BackgroundInhibitor of apoptosis proteins (IAPs) belong to a pivotal antiapoptotic protein family that plays a crucial role in tumorigenesis, cancer progression, chemoresistance and poor patient-survival. X-linked inhibitor of apoptosis protein (XIAP) is
Man Kit Tse, Sin Kam Hui, Yinhua Yang, Si-Tao Yin, Hong-Yu Hu, Bing Zou, Benjamin Chun Yu Wong, Kong Hung Sze   +7 more
doaj   +1 more source

XIAP variants in male Crohn's disease [PDF]

Gut, 2014
The genetic basis of inflammatory bowel disease (IBD) is incompletely understood. The aim of this study was to identify rare genetic variants involved in the pathogenesis of IBD.Exome sequencing and immunological profiling were performed in a patient with early onset Crohn's disease (CD).
Yvonne, Zeissig, Britt-Sabina, Petersen, Snezana, Milutinovic, Esther, Bosse, Gabriele, Mayr, Kenneth, Peuker, Jelka, Hartwig, Andreas, Keller, Martina, Kohl, Martin W, Laass, Susanne, Billmann-Born, Heide, Brandau, Alfred C, Feller, Christoph, Röcken, Martin, Schrappe, Philip, Rosenstiel, John C, Reed, Stefan, Schreiber, Andre, Franke, Sebastian, Zeissig   +19 more
openaire   +2 more sources

X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

Diagnostic Pathology, 2011
Background It's well recognized that X-linked inhibitor of apoptosis (XIAP) was the most potent caspase inhibitor and second mitochondria-derived activator of caspase (Smac) was the antagonist of XIAP. Experiments in vitro identified that down regulation
Peng Bofang, Zhou Hongyuan, Li Feng, Tang Yun, Zhu Jianhua, Zhang Yutao, Zhou Chifeng, Fu Rong   +7 more
doaj   +1 more source

CSR1 inhibits XIAP

The FASEB Journal, 2012
CSR1 is a tumor suppressor gene located at 8p21, a region that is frequently deleted in a variety of human malignancies. Previous studies indicated that expression of CSR1 induced cell death. In this study, we identified that CSR1 interacted with XIAP through a Yeast Two‐hybrid screening analysis.
Jianhua Luo, Zhong-Liang Zheng, Yan P Yu
openaire   +1 more source