Results 31 to 40 of about 17,869 (171)

XIAP-mediated neuroprotection in retinal ischemia [PDF]

Gene Therapy, 2005
Retinal ischemia results in the loss of vision in a number of ocular diseases including acute glaucoma, diabetic retinopathy, hypertensive retinopathy and retinal vascular occlusion. Recent studies have shown that most of the neuronal death that leads to loss of vision results from apoptosis.
J, Renwick, M A, Narang, S G, Coupland, J Y, Xuan, A N, Baker, J, Brousseau, D, Petrin, R, Munger, B C, Leonard, W W, Hauswirth, R G, Korneluk, C, Tsilfidis   +11 more
openaire   +2 more sources

Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis

Indian Journal of Ophthalmology, 2017
Purpose: Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers.
Perumal Jayaraj, Seema Sen, P S Dhanaraj, Romika Jhajhria, Shalu Singh, Vijay Kumar Singh   +5 more
doaj   +1 more source

Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway. [PDF]

PLoS ONE, 2009
Myotube apoptosis occurs normally during muscle development and aging but it can lead to destruction of skeletal muscle in neuromuscular diseases. Therefore, understanding how myotube apoptosis is regulated is important for developing novel strategies ...
Michelle I Smith, Yolanda Y Huang, Mohanish Deshmukh   +2 more
doaj   +1 more source

The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization

Journal of Translational Medicine, 2007
XIAP up-regulation is associated with chemotherapy resistance. Phenoxodiol causes XIAP degradation and chemotherapy sensitization in ovarian cancer. Here we assessed XIAP expression in melanomas, using tissue microarrays containing 436 melanomas and 336 ...
Camp Robert L, Ariyan Stephan, Sznol Mario, Alvero Ayesha B, McCarthy Mary M, Kluger Harriet M, Rimm David L, Mor Gil   +7 more
doaj   +1 more source

XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively.

PLoS Pathogens, 2023
XIAP is an endogenous inhibitor of cell death and inactivating mutations of XIAP are responsible for X-linked lymphoproliferative disease (XLP-2) and primary immunodeficiency, but the mechanism(s) behind these contradictory outcomes have been unclear. We
Parva Thakker, Ardeshir Ariana, Stephanie Hajjar, David Cai, Dikchha Rijal, Subash Sad   +5 more
doaj   +1 more source

Subcellular localization of X-linked inhibitor of apoptosis protein (XIAP) in cancer: Does that matter?

BBA Advances, 2022
X-linked inhibitor of apoptosis protein (XIAP) finely tunes the balance between survival and death to control homeostasis. XIAP is found aberrantly expressed in cancer, which has been shown to promote resistance to therapy-induced apoptosis and confer ...
BS Mendonça, CA Ferreira, RC Maia, G Nestal de Moraes   +3 more
doaj   +1 more source

XIAP: Cell death regulation meets copper homeostasis [PDF]

Archives of Biochemistry and Biophysics, 2007
X-linked inhibitor of apoptosis (XIAP), traditionally known as an anti-apoptotic protein, has recently been shown to be involved in copper homeostasis. XIAP promotes the ubiquitination and degradation of COMMD1, a protein that promotes the efflux of copper from the cell.
Arjmand R, Mufti, Ezra, Burstein, Colin S, Duckett   +2 more
openaire   +2 more sources

XAF1 (XIAP associated factor-1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on XAF1 (XIAP associated factor-1), with data on DNA, on the protein encoded, and where the gene is implicated.
S Plenchette, WG Fong, RG Korneluk
openaire   +1 more source

Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer

Cell Adhesion & Migration, 2019
Our previous studies have demonstrated that XIAP promotes bladder cancer metastasis through upregulating RhoGDIβ/MMP-2 pathway. However, the molecular mechanisms leading to the XIAP upregulation was unclear.
Honglei Jin, Lei Xue, Lan Mo, Dongyun Zhang, Xirui Guo, Jiheng Xu, Jingxia Li, Minggang Peng, Xuewei Zhao, Minghao Zhong, Dazhong Xu, Xue-Ru Wu, Haishan Huang, Chuanshu Huang   +13 more
doaj   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source