Results 71 to 80 of about 17,869 (171)

Disease‐causing mutations in the XIAP BIR2 domain impair NOD2‐dependent immune signalling

EMBO Molecular Medicine, 2013
X‐linked Inhibitor of Apoptosis (XIAP) is an essential ubiquitin ligase for pro‐inflammatory signalling downstream of the nucleotide‐binding oligomerization domain containing (NOD)‐1 and ‐2 pattern recognition receptors.
Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker‐Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand, Mads Gyrd‐Hansen   +9 more
doaj   +1 more source

Gene transfection mediated by polyethyleneimine-polyethylene glycol nanocarrier prevents cisplatin-induced spiral ganglion cell damage

Neural Regeneration Research, 2015
Polyethyleneimine-polyethylene glycol (PEI-PEG), a novel nanocarrier, has been used for transfection and gene therapy in a variety of cells. In our previous study, we successfully carried out PEI-PEG-mediated gene transfer in spiral ganglion cells.
Guan-gui Chen, Min Mao, Li-zi Qiu, Qi-ming Liu   +3 more
doaj   +1 more source

Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease

Scientific Reports
X-linked inhibitor of apoptosis protein (XIAP) deficiency causes refractory inflammatory bowel disease. The XIAP protein plays a pivotal role in the pro-inflammatory response through the nucleotide-binding oligomerization domain-containing signaling ...
Juhwan Lee, Kyoung Mi Sim, Mooseok Kang, Hyun Ju Oh, Ho Jung Choi, Yeong Eun Kim, Chan-Gi Pack, Kyunggon Kim, Kyung Mo Kim, Seak Hee Oh, Inki Kim, Iksoo Chang   +11 more
doaj   +1 more source

The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats

Cellular Physiology and Biochemistry, 2016
Background/Aims: To investigate the effect of cognitive impairment and X-linked inhibitor of apoptosis protein (XIAP) on glucolipid metabolism. Materials and Methods: β-amyloid (Aβ 1-42) was injected into the hippocampus of rats to establish a cognitive ...
Chunbo Xia, Lin Zhu, Wenhua Shao, Sisi Mi, Sen Du, Lin Ye, Manjun Liu, YongJun Pang, Linlin Nong, Changwen Jiang, Hailu Zhao, Guangying Qi   +11 more
doaj   +1 more source

Induction and redistribution of XAF1, a new antagonist of XIAP in the rat brain after transient focal ischemia

Neurobiology of Disease, 2005
Apoptotic cell death occurs in neurons after cerebral ischemia. To investigate the molecular basis of this mechanism of cell death, we explored the expression and localization of Smac/DIABLO, a newly identified mitochondrial apoptogenic molecule, and ...
M. Siegelin, O. Touzani, J. Toutain, P. Liston, A. Rami   +4 more
doaj   +1 more source

Effects of apoptosis protein XIAP inhibitor on the apoptosis and sensitivity of chemotherapy in A549 cell

Chinese Journal of Lung Cancer, 2008
Background and objective X-linked inhibitor of apoptosis protein (XIAP) is a newly discovered inhibitor of apoptosis protein which prevents apoptosis by inhibiting the activation of caspase. After down-regulating XIAP gene expression in A549 cells, a non-
Guangjie SUI, Hongyan QU, Fuhui CHEN
doaj  

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

Cell Reports, 2014
X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using
Monica Yabal, Nicole Müller, Heiko Adler, Nathalie Knies, Christina J. Groß, Rune Busk Damgaard, Hirokazu Kanegane, Marc Ringelhan, Thomas Kaufmann, Mathias Heikenwälder, Andreas Strasser, Olaf Groß, Jürgen Ruland, Christian Peschel, Mads Gyrd-Hansen, Philipp J. Jost   +15 more
doaj   +1 more source

XIAP gene expression and function is regulated by autocrine and paracrine TGF-β signaling

Molecular Cancer, 2010
Background X-linked inhibitor of apoptosis protein (XIAP) is often overexpressed in cancer cells, where it plays a key role in survival and also promotes invasiveness.
Van Themsche Céline, Chaudhry Parvesh, Leblanc Valérie, Parent Sophie, Asselin Eric   +4 more
doaj   +1 more source

XIAP is not required for human tumor cell survival in the absence of an exogenous death signal

BMC Cancer, 2010
Background The X-linked Inhibitor of Apoptosis (XIAP) has attracted much attention as a cancer drug target. It is the only member of the IAP family that can directly inhibit caspase activity in vitro, and it can regulate apoptosis and other biological ...
Peach Robert, Scott Fiona L, Sensintaffar John, Hager Jeffrey H   +3 more
doaj   +1 more source

Cnidaria XIAP activates caspase-mediated cell death

International Journal of Biological Macromolecules
In vertebrate, X-linked inhibitor of apoptosis (XIAP) is a potent inhibitor of apoptosis. XIAP inhibits apoptosis by interacting with proapoptotic caspases via the baculovirus IAP repeat (BIR) domains and mediating caspase ubiquitination via the really interesting new gene (RING) domain and ubiquitin-associated (UBA) domain.
Yuan, Chen, Meng, Wu, Zihao, Yuan, Qingyue, Wang, Hang, Xu, Li, Sun   +5 more
openaire   +2 more sources