Results 251 to 260 of about 35,510 (301)

Myonuclear domain-associated and central nucleation-dependent spatial restriction of dystrophin protein expression in a novel DMD mouse model

Chwalenia K, Feng V, Hemmer N, Hildyard JC, Roskrow LE, Piercy RJ, Wang ET, Aartsma-Rus A, van Putten M, Wood MJ, Roberts TC.   +10 more
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Targeting Xist with compounds that disrupt RNA structure and X inactivation

Nature, 2022
Rodrigo Aguilar, Noreen F Rizvi, Maulik D Badmalia   +2 more
exaly   +2 more sources

A protein assembly mediates Xist localization and gene silencing

Nature, 2020
Nuclear compartments have diverse roles in regulating gene expression, yet the molecular forces and components that drive compartment formation remain largely unclear1.
Amy Pandya-Jones, Yolanda Markaki, Jacques Serizay   +2 more
exaly   +2 more sources

lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer’s disease

Journal of neurogenetics, 2022
Alzheimer’s disease (AD) is the leading cause of dementia globally, but effective treatment is lacking. We aimed to explore lncRNA XIST role in AD and the mechanisms involved in the effect of changes in lncRNA XIST on the expression of Aβ-degrading ...
Xiwei Yan, Huai-Jun Liu, Yuanyuan Hong, Ting Meng, Jun Du, Cheng Chang   +5 more
semanticscholar   +1 more source

METTL14‐mediated lncRNA XIST silencing alleviates GDM progression by facilitating trophoblast cell proliferation and migration via the miR‐497‐5p/FOXO1 axis

Journal of biochemical and molecular toxicology, 2023
Gestational diabetes mellitus (GDM), a prevalent complication during the gestation period, has been linked to impaired proliferation and migration of trophoblasts causing placental maldevelopment.
Yanchuan Li, Yanfeng Liu, Xiao Yao, Haili Wang, Ziyun Shi, Meiqing He   +5 more
semanticscholar   +1 more source

Xist RNA in action: Past, present, and future

PLoS Genetics, 2019
In mammals, dosage compensation of sex chromosomal genes between females (XX) and males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive-specific transcript (Xist) long noncoding RNA is indispensable for XCI and initiates
Agnese Loda, Edith Heard
exaly   +2 more sources

XIST/miR-34a-5p/PDL1 axis regulated the development of lung cancer cells and the immune function of CD8+ T cells

Journal of Receptor and Signal Transduction Research, 2022
Purpose Long non-coding RNA (lncRNA) XIST has been shown to be involved in the immune escape of breast cancer, but it is unclear whether it is involved in the immune escape of lung cancer, so it will be discussed in this study.
Jing Li, L. Che, Chang Xu, D. Lu, Yan Xu, Mengru Liu, Wenshu Chai   +6 more
semanticscholar   +1 more source

The Xist Locus

2019
Chromosome balance is critical for normal development. When a condition with extra or missing chromosome exists, the effects are damaging if the balance is not somehow restored. A classic example is Down’s syndrome in humans, which is characterized by trisomy 21.
Gartler, Stanley M., Goldman, Michael A., Cerase, Andrea   +2 more
openaire   +2 more sources

Visualizing Xist RNA dynamics

Science, 2021
X-Inactivation The noncoding RNA Xist, which controls the process of X chromosome inactivation in mammals, accumulates and spreads over the chromosome from which it is transcribed. The underlying basis for this unusual behavior is poorly understood. Using a new imaging approach called RNA-SPLIT for time-resolved analysis of Xist RNA molecules at super ...
openaire   +1 more source