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Xist and X chromosome inactivation
Molecular and Cellular Endocrinology, 1998X inactivation acts in female mammals to equalise X-linked gene dosage between XX females and XY males. X inactivation is controlled by a single X-linked cis-acting locus called the X inactivation centre (Xic). In 1991 the Xist gene was identified as a candidate for the Xic. Xist is expressed in all adult female tissues, but only from the allele on the
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2018
Live imaging gives additional layers of information such as physical dynamics of a molecule of your interest. Aptamer-based green fluorescent protein (GFP) labeling is suitable for visualization of RNA molecules. Here we describe a method to visualize Xist RNA using the Bgl aptamer system.
Osamu, Masui +2 more
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Live imaging gives additional layers of information such as physical dynamics of a molecule of your interest. Aptamer-based green fluorescent protein (GFP) labeling is suitable for visualization of RNA molecules. Here we describe a method to visualize Xist RNA using the Bgl aptamer system.
Osamu, Masui +2 more
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A revision of the human XIST gene organization and structural comparison with mouse Xist
Mammalian Genome, 2000The XIST gene plays an essential role in X Chromosome (Chr) inactivation during the early development of female humans. It is believed that the XIST gene, not encoding a protein, functions as an RNA. The XIST cDNA is unusually long, as its full length is reported to be 16.5 kilobase pairs (kb).
Y K, Hong, S D, Ontiveros, W M, Strauss
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Science Translational Medicine, 2013
Harnessing the cell’s ability to silence X chromosomes yields a promising tool to inhibit the extra chromosome 21 in human induced pluripotent stem cells from Down syndrome patients.
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Harnessing the cell’s ability to silence X chromosomes yields a promising tool to inhibit the extra chromosome 21 in human induced pluripotent stem cells from Down syndrome patients.
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X chromosome inactivation and the Xist gene
Cellular and Molecular Life Sciences (CMLS), 1998Recent years have seen rapid progress towards understanding the molecular mechanisms involved in X chromosome inactivation (X inactivation). This progress has largely revolved around the discovery of the X inactive specific transcript (Xist) gene, which is known now to represent the master switch locus regulating X inactivation.
N, Brockdorff, S M, Duthie
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Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells
Clinical and Translational Oncology, 2023M. Farzaneh +10 more
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Science Signaling, 2008
X chromosome inactivation in stem cells is reversed, a step in allowing them to become pluripotent, when three factors repress the inactivation RNA.
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X chromosome inactivation in stem cells is reversed, a step in allowing them to become pluripotent, when three factors repress the inactivation RNA.
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IRF-1-inhibited lncRNA XIST regulated the osteogenic differentiation via miR-450b/FBXW7 axis
Apoptosis, 2023Chenyang Song +3 more
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We identify here through the study of total transcription in human cells engineered to express an Xist transgene, and in human pluripotent stem cells selected at the clonal level for Xist positivity (Xist+ hES), and proteomic study of Xist interacting proteins a network of epigenetic molecules whose expression is controlled by Xist.
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