Results 271 to 280 of about 35,510 (301)

The role of Xist in X-inactivation

Current Opinion in Genetics & Development, 1998
The past year has seen important progress in our understanding of the role of the X inactive specific transcript gene (Xist) in the initiation and propagation of X-inactivation. A 35 kb Xist transgene had been shown to recapitulate the functions of the X-inactivation centre, progress has been made towards indentifying factors controlling the randomness
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Xist

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
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Rnf8 control of Xist.

The damage signal is displayed by addition of a H2AX mark, recognized by Tp53bp1 and E3 ligases Rnf8 and Rnf168, in addition to MDC1, XRCC5 and XRCC6, and DNA-PKc, whereupon it is transduced to BRCA1 along with Rad family genes, as well all ATM/ATR and CHEK1/2.
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Translesion synthesis activates Xist.

DNA polymerases are categorized based on their functions at the genomic DNA, in eukaryotes or prokaryotes, and in repair and/or replication. Family Y polymerases function in the translesion synthesis pathway that resolves fork structures associated with stalled replication.
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Counting on Xist

Nature Genetics, 1998
Laura Carrel, Huntington F. Willard
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Xist Locus

2013
S.M. Gartler, M.A. Goldman
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Xist controls GLI3 activation.

Oncogenes and homeobox transcription factors signal amongst each other and in response to one another during transformation and repair of the DNA in following damage of the DNA. We identified a homeobox transcription factor cascade that is required for transformation in human cells including PAX8 and HoxC/D family members. Homeobox factors that control
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Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading

Science, 2021
Lisa Rodermund, Heather A Coker, Roel Oldenkamp   +2 more
exaly  

Xisting Synergy

Science, 2008
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Combination of human and mouse XIST domains generates a minimal functional XIST

X-chromosome inactivation (XCI) is an essential process in eutherian mammals to compensate dosage between females and males. XCI is triggered by XIST, a long non-coding RNA that acts as a scaffold for the recruitment of the needed heterochromatic changes to keep one X chromosome inactivated.
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