Results 41 to 50 of about 673 (120)

The suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma

Scientific Reports, 2020
NONO-TFE3 RCC is a subtype of Xp11.2 translocation renal cell carcinoma (RCC). So far, only a small amount of NONO-TFE3 RCC have been reported owing to lack of effective diagnosis methods.
Ning Liu, Wei Guo, Qiancheng Shi, Wenyuan Zhuang, Xiaohong Pu, Shaoyu Chen, Feng Qu, Linfeng Xu, Xiaozhi Zhao, Xiaogong Li, Gutian Zhang, Hongqian Guo, Weidong Gan, Dongmei Li   +13 more
doaj   +1 more source

Emerging Role of ctDNA Fragmentomics and Epigenetic Signatures in the Early Detection, Minimal Residual Disease Assessment, and Precision Monitoring of Renal Cell Carcinoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Renal cell carcinoma (RCC) presents a significant global health challenge, with a substantial proportion of patients diagnosed with advanced or metastatic disease due to the limitations of current diagnostic imaging and the lack of validated non‐invasive biomarkers.
Hossam Kamli, Najeeb Ullah Khan
wiley   +1 more source

Adult Patient with Synchronous Gastrointestinal Stromal Tumor and Xp11 Translocation-Associated Renal Cell Carcinoma: A Unique Case Presentation with Discussion and Review of Literature

Case Reports in Urology, 2015
Gastrointestinal stromal tumor (GIST) is the most common primary mesenchymal tumor of the gastrointestinal tract. This entity comprises a wide spectrum of tumors that vary from benign to overtly malignant, with the majority of these tumors harboring ...
Vanda Farahmand Torous, Albert Su, David Y. Lu, Sarah M. Dry   +3 more
doaj   +1 more source

Preoperative neutrophil-to-lymphocyte ratio predicts the surgical outcome of Xp11.2 translocation/TFE3 renal cell carcinoma patients

BMC Urology, 2018
Background The preoperative neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CRP/Alb ratio) and platelet-to-lymphocyte ratio (PLR) have been demonstrated to predict the clinical outcome of various human cancer, including renal cell
Sezim Agizamhan, Feng Qu, Ning Liu, Jing Sun, Wei Xu, Lihua Zhang, Hongqian Guo, Weidong Gan   +7 more
doaj   +1 more source

Recent developments in eosinophilic renal neoplasms: what's new, true and important?

Histopathology, Volume 88, Issue 1, Page 166-192, January 2026.
Recent developments and acquired knowledge on newer renal entities with eosinophilic cytoplasm opened insights into the clinical, pathological, immunohistochemical, molecular, epidemiological aspects, and the prognosis of these entities. We emphasize the role of routine morphology, aided by appropriate and select immunohistochemistry, as essential keys
Kiril Trpkov, Farshid Siadat, Rola Saleeb   +2 more
wiley   +1 more source

Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature

Diagnostic Pathology, 2009
The recently recognized renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children.
Surti Urvashi, Parwani Anil V, Armah Henry B, Bastacky Sheldon I   +3 more
doaj   +1 more source

Remarkable Response to Immunotherapy and VEGFR Inhibitor in Xp11 Translocation Renal Cell Carcinoma in a 17‐Year‐Old Adolescent

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
Background Xp11 translocation renal cell carcinoma (tRCC) is a rare and aggressive renal cancer characterized by gene fusion involving TFE3. It accounts for < 5% of renal cancers and shows variable responses to conventional antivascular endothelial growth factor therapies.
Piyarat Limpawittayakul, Narongchai Teerayathanakul, Farid Cherbal   +2 more
wiley   +1 more source

A Rare Case of TFE3‐Rearranged and SMARCB1‐Mutated Renal Cell Carcinoma: Diagnostic and Therapeutic Complexities

Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
Renal cell carcinoma (RCC) represents the majority of kidney malignancies, with clear cell RCC being the most common subtype. However, recent advances in tumor genomics have refined RCC classification, highlighting rare molecular subtypes such as TFE3‐rearranged and SMARCB1‐deficient RCCs.
Paul J. Pecorin, Nyembezi Dhliwayo, Trevor Christ, Thomas Westbrook, Harleen Khatra   +4 more
wiley   +1 more source

The Role of Glycoprotein Non‐Metastatic Melanoma Protein B (GPNMB) in Tumors and Other Diseases

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Glycoprotein non‐metastatic melanoma protein B (GPNMB) is is widely involved in biological processes such as tissues, cells, metabolism and immunity, regulates multiple signaling pathways, and plays an important role in the occurrence and development of various diseases, including tumors.
Zhenyu Wu, Na Sun, Man Qu, Xia Kang, Yi Zhang, Xiaowei Qi   +5 more
wiley   +1 more source

Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N 6-methyladenosine of PARP1 mRNA and downregulating PTEN

Journal of Hematology & Oncology, 2021
Background NONO-TFE3 translocation renal cell carcinoma (NONO-TFE3 tRCC) is one subtype of RCCs associated with Xp11.2 translocation/TFE3 gene fusions RCC (Xp11.2 tRCCs). Long non-coding RNA (lncRNA) has attracted great attention in cancer research.
Lei Yang, Yi Chen, Ning Liu, QianCheng Shi, Xiaodong Han, Weidong Gan, Dongmei Li   +6 more
doaj   +1 more source