Results 1 to 10 of about 5,684 (129)

Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma

Frontiers in Oncology, 2022
BackgroundThis study aimed to investigate the expression profile of TFE3 in renal cell carcinoma (RCC) and the clinicopathological features as well as prognosis of TFE3-positive RCC.MethodsTissue sections from 796 patients with RCC were collected for ...
Weidong Gan, Wenliang Ma
exaly   +3 more sources

ASPSCR1: TFE3 Fusion‐Positive Epithelioid Angiomyolipoma/PEComa Lacking Melanocytic Markers: A Case Report [PDF]

IJU Case Reports
Introduction Epithelioid angiomyolipoma is a rare perivascular epithelioid cell tumor subtype with malignant potential. Its morphology mimics renal cell carcinoma, posing diagnostic challenges.
Yuka Kondo, Yoji Nagashima, Kenji Zennami, Megumi Sato, Sayaka Sumiyoshi, Akihiko Sugimoto, Madoka Isomura, Kiyoshi Takahara, Sachiko Minamiguchi   +8 more
doaj   +2 more sources

The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC [PDF]

Neoplasia: An International Journal for Oncology Research
TFE3-rearranged renal cell carcinoma (TFE3-RCC) is an aggressive kidney cancer driven by oncogenic TFE3 fusion transcription factors, yet the molecular machinery that enables these fusions to reprogram transcription and drive tumor growth remains poorly ...
Shoichiro Kuroda, Shintaro Funasaki, Hidekazu Nishizawa, Laura S. Schmidt, Ryoma Kurahashi, Takaaki Ito, Yuichiro Arima, Miwa Tanaka, Atsuya Kitada, Amy M. James, Hisashi Hasumi, Ryosuke Jikuya, Kazuhide Makiyama, Daisuke Kurotaki, Takashi Minami, Simone Difilippantonio, W. Marston Linehan, Yuichi Oike, Tomohiro Sawa, Yasuhito Tanaka, Toshio Suda, Ryuji Yokokawa, Takuro Nakamura, Masaya Baba, Tomomi Kamba   +24 more
doaj   +2 more sources

TFE3 regulates whole‐body energy metabolism in cooperation with TFEB

EMBO Molecular Medicine, 2017
TFE3 and TFEB are members of the MiT family of HLH–leucine zipper transcription factors. Recent studies demonstrated that they bind overlapping sets of promoters and are post‐transcriptionally regulated through a similar mechanism.
Tiemo J Klisch, Marco Sandri, Andrea Armani   +2 more
exaly   +2 more sources

TFE3‐DualNet: An Interpretable Foundation Model‐Based Deep Learning Ensemble for Diagnosing TFE3‐Rearranged Renal Cell Carcinoma From Whole‐Slide Images in a Two‐Center Cohort [PDF]

Cancer Medicine
Background TFE3‐rearranged renal cell carcinoma (TFE3‐rRCC) is a rare, aggressive subtype that predominantly affects adolescents and young adults. Its marked morphologic heterogeneity can delay recognition and downstream confirmatory testing.
Yu‐Hang Chen, Quan‐Hui Xu, Hao‐Hua Yao, Ke‐Zhi Liu, Cheng‐Peng Gui, Liang‐Min Fu, Ying‐Han Wang, Jiang‐Quan Zhu, Jun‐Cai Li, Min‐Yu Chen, Kang‐Bo Huang, Han‐Sen Lin, Bing Liao, Yun Cao, Jin‐Huan Wei, Peng‐Ju Li, Jun‐Hang Luo, Jia‐Zheng Cao   +17 more
doaj   +2 more sources

TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma

Cell Reports
Summary: Translocation renal cell carcinoma (tRCC) presents a significant clinical challenge due to its aggressiveness and limited treatment options.
Danfeng Cai
exaly   +3 more sources

TFE3 fusion proteins drive TFE3 rearranged renal cell carcinoma progression via PGC-1α-mediated fatty acid oxidation [PDF]

Frontiers in Immunology
IntroductionTFE3 rearranged renal cell carcinoma (TFE3 rRCC) is a distinct and aggressive subtype of RCC characterized by poor prognosis. While TFE3 fusion proteins are central to its pathogenesis, their specific roles in tumor progression, particularly ...
Fan Feng, Fan Feng, Yanhao Xu, Zhenggen Deng, Xiang Dong, Guijuan Chen, Guijuan Chen, Wenliang Ma, Dongmei Li, Dongmei Li, Weidong Gan   +10 more
doaj   +2 more sources

TFE3 gene rearrangement and protein expression contribute to a poor prognosis of renal cell carcinoma

Heliyon, 2023
Background: TFE3-rearranged renal cell carcinoma (TFE3-rearranged RCC) is a type of kidney cancer with a low incidence, with no consensus about whether it has a worse prognosis than clear cell renal cell carcinoma (ccRCC).
Junyi Lin, Zhuang Tang, Chengjunyu Zhang, Wen Dong, Yeqing Liu, Hao Huang, Hao Liu, Jian Huang, Tianxin Lin, Xu Chen   +9 more
doaj   +1 more source

Emerging roles of TFE3 in metabolic regulation

Cell Death Discovery, 2023
TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic ...
Xingyu Li, Yongming Chen, Siqiao Gong, Huixia Chen, Huafeng Liu, Xiaoyu Li, Junfeng Hao   +6 more
doaj   +1 more source

TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma

Analytical Cellular Pathology, 2021
Background. Accumulating evidence shows that autophagy plays a vital role in tumor occurrence, development, and metastasis and even determines tumor prognosis.
Hongsheng Lu, Chumeng Zhu, Yanyun Ruan, Lilong Fan, Kena Wei, Zhaohui Yang, Qi Chen   +6 more
doaj   +1 more source