Results 21 to 30 of about 5,684 (129)

Xp11.2 Translocation Renal Cell Carcinoma With TFE3 Rearrangement: Distinct Morphological Features and Prognosis With Different Fusion Partners

Frontiers in Oncology, 2021
BackgroundRenal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion is a rare and new subtype of RCC and was classified by the WHO in 2004. Since then, multiple 5′ fusion partners for TFE3 have been reported; however, the impact of
Yan Ge, Xingtao Lin, Qingling Zhang, Danyi Lin, Luqiao Luo, Huiling Wang, Zhi Li   +6 more
doaj   +1 more source

Malignant MITF-Rearranged PEComa With Novel EEF1A1::MITF Fusion. [PDF]

Genes Chromosomes Cancer
ABSTRACT MITF‐rearranged PEComas are rare, and their relationship to MITF‐altered melanocytic tumors remains incompletely characterized. We report a malignant superficial soft tissue neoplasm of the thigh in a 45‐year‐old woman harboring a novel EEF1A1::MITF fusion. The tumor was composed of epithelioid to plump spindle cells arranged in sheets, nests,
Raney S, Karunamurthy A, Ho J, Bubar R, Mohebnasab M, Skaugen J, Elmoryah M, Nacev B, McGough R, John I.   +9 more
europepmc   +2 more sources

Case Reports of TFE3-Rearranged Renal Cell Carcinoma: FDG-PET Uptake Might Help Diagnosis

Journal of Kidney Cancer and VHL, 2023
Translocation and transcription factor E3 (TFE3)-rearranged renal cell carcinoma (RCC) is a rare subtype of RCCs characterised by the fusion of the TFE3 transcription factor genes on chromosome Xp11.2 with one of the multiple genes.
Sho Murakami, Keita Nagawa, Takanori Inui, Aya Yamamoto, Mizuka Suzuki, Fumitaka Koga, Toru Motoi, Yasunobu Takaki   +7 more
doaj   +1 more source

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

eLife, 2018
The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner.
Owen A Brady, Eutteum Jeong, José A Martina, Mehdi Pirooznia, Ilker Tunc, Rosa Puertollano   +5 more
doaj   +1 more source

The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour

Analytical Cellular Pathology, 2020
The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored.
Luting Zhou, Anran Wang, Guoli Yu, Jun Zhou, Haimin Xu, Chaofu Wang   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ARID2 Deficiency Enhances Tumor Progression via ERBB3 Signaling in TFE3-Rearranged Renal Cell Carcinoma

Current Issues in Molecular Biology
TFE3-rearranged Renal Cell Carcinoma (TFE3-RCC) is an aggressive subtype of RCC characterized by Xp11.2 rearrangement, leading to TFE3 fusion proteins with oncogenic potential.
Jinglong Tang, Shintaro Funasaki, Hidekazu Nishizawa, Shoichiro Kuroda, Takanobu Motoshima, Chang Wu, Amany Sayed Mawas, Yorifumi Satou, Yuichiro Arima, Hisashi Hasumi, Ryosuke Jikuya, Kazuhide Makiyama, Yuichi Oike, Yasuhito Tanaka, Masaya Baba, Tomomi Kamba   +15 more
doaj   +1 more source

p53 aberration and TFE3 gene amplification may be predictors of adverse prognosis in epithelioid angiomyolipoma of the kidney

Diagnostic Pathology, 2023
Background Although epithelioid angiomyolipoma of the kidney has been studied by several groups, the reported prevalence of malignant behavior remains uncertain and there are not yet definitive predictive biomarkers.
Yanning Zhang, Xuejing Wei, Xiaojing Teng, Guangyong Chen   +3 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

MED15-TFE3 rearranged renal cell carcinoma: a subtype of TFE3-rearranged renal cell carcinoma with unique clinicopathologic features and better prognosis

World Journal of Surgical Oncology
Background MED15-TFE3 rearranged renal cell carcinoma (MED15-TFE3 rRCC) is a rare subtype of TFE3-rearranged renal cell carcinoma (TFE3 rRCC). To date, only 47 cases of MED15-TFE3 rRCC (including 2 cases from our institution) have been reported worldwide.
Zhenggen Deng, Yanhao Xu, Enjia Duan, Xiaopo Zhang, Xiang Dong, Hongqian Guo, Weidong Gan   +6 more
doaj   +1 more source