Results 11 to 20 of about 5,684 (129)

Clinical Outcomes, Treatment Patterns, and Molecular Heterogeneity of TFE3-Rearranged Renal Cell Carcinoma: A Multicenter Real-World Study. [PDF]

Cancer Med
ABSTRACT Background TFE3‐rearranged renal cell carcinoma (TFE3‐rRCC) is uncommon and encompasses biologically diverse tumors, while evidence to guide systemic treatment remains sparse. We examined clinical outcomes, treatment patterns, and molecular features in a multicenter real‐world cohort.
Zhu S, Zhou S, Tian X, Wang J, Wang Z, Jiang J, Liu Q, Gou X, Zhou X, Gu J, Yang J, Chen J, Chen S, Wang W, Anwaier A, Chang K, Qu Y, Brugarolas J, Xu W, Zhang H, Ye D.   +20 more
europepmc   +2 more sources

Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea. [PDF]

Glia
Generation and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Williamson MR, Botas J, Hedayatpour MJ, Zlatkov T, Harmanci AS, Yates CJ, Nobleza K, Ailani R, Adler AC, Kheradmand F, Lee HK, Deneen B, Jeong HH, Chandrakantan A.   +13 more
europepmc   +2 more sources

LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner

Journal of Experimental & Clinical Cancer Research, 2023
Background NONO-TFE3 rearranged renal cell carcinoma (NONO-TFE3 rRCC) is one of a subtype of TFE3 rRCCs with high malignancy and poor prognosis. Compared with clear cell RCC, NONO-TFE3 rRCC shows a preference for mitochondrial respiration.
Yi Chen, Yanwen Lu, Lei Yang, Wenliang Ma, Yuhan Dong, Shuoming Zhou, Ning Liu, Weidong Gan, Dongmei Li   +8 more
doaj   +1 more source

Exploration of clinicopathological features of rearranged renal cell carcinoma and TFE3, TFEB, and ALK staining performance in renal entities

Heliyon, 2023
Rearranged renal cell carcinomas (RCC) are rare types of kidney cancer. The clinicopathological features of rearranged RCC require further validation. The pathological diagnosis usually depends on immunohistochemistry and molecular analysis.
Yang Liu, Xiangyun Li, Yue Fan, Haimin Xu, Yijin Gu, Lei Dong, Luting Zhou, Xiaoqun Yang, Chaofu Wang   +8 more
doaj   +1 more source

PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. [PDF]

PLoS ONE, 2017
PRCC-TFE3 renal cell carcinoma (RCC) is one of the most common types of Xp11.2 translocation renal cell carcinoma (tRCC), of which the diagnosis mainly relies on reverse transcription-polymerase chain reaction (RT-PCR) or chromosomal analysis in fresh ...
Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan, Dongmei Li, Hongqian Guo   +7 more
doaj   +1 more source

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.

PLoS ONE, 2010
BackgroundGermline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé syndrome.
Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Masaya Baba, Laura S Schmidt, W Marston Linehan   +5 more
doaj   +1 more source

TFE3-Mediated Autophagy is Involved in Dopaminergic Neurodegeneration in Parkinson’s Disease

Frontiers in Cell and Developmental Biology, 2021
Impairment of autophagy has been strongly implicated in the progressive loss of nigral dopaminergic neurons in Parkinson’s disease (PD). Transcription factor E3 (TFE3), an MiTF/TFE family transcription factor, has been identified as a master regulator of
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang   +7 more
doaj   +1 more source

The suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma

Scientific Reports, 2020
NONO-TFE3 RCC is a subtype of Xp11.2 translocation renal cell carcinoma (RCC). So far, only a small amount of NONO-TFE3 RCC have been reported owing to lack of effective diagnosis methods.
Ning Liu, Wei Guo, Qiancheng Shi, Wenyuan Zhuang, Xiaohong Pu, Shaoyu Chen, Feng Qu, Linfeng Xu, Xiaozhi Zhao, Xiaogong Li, Gutian Zhang, Hongqian Guo, Weidong Gan, Dongmei Li   +13 more
doaj   +1 more source

SEARCH FOR ARE REGULATORY SEQUENCES IN GENES of MASTER REGULATORS OF autophagy and LYSOSOMAL BIOGENESIS TFEB AND TFE3

Сибирский научный медицинский журнал, 2019
Transcription factors TFEB and TFE3 are the master regulators of lysosomal biogenesis and autophagy and control most of the protein genes involved in the formation of lysosomes by interacting with the promoters of these genes containing the regulatory ...
A. V. Chechushkov, E. B. Menshchikova
doaj   +1 more source

TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas

Journal of Experimental & Clinical Cancer Research, 2019
Background Xp11.2 translocation renal cell carcinoma (tRCC) is mainly caused by translocation of the TFE3 gene located on chromosome Xp11.2 and is characterized by overexpression of the TFE3 fusion gene. Patients are diagnosed with tRCC usually before 45 
Xiaoqin Yin, Bo Wang, Weidong Gan, Wenyuan Zhuang, Zou Xiang, Xiaodong Han, Dongmei Li   +6 more
doaj   +1 more source