Results 21 to 30 of about 673 (120)

Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB fusion with concurrent TFEB amplification

Genes, Chromosomes and Cancer, Volume 62, Issue 6, Page 353-360, June 2023., 2023
Abstract Transcription factor EB (TFEB)‐rearranged renal cell carcinoma (RCC) exhibits diverse gene fusion patterns and heterogeneous clinicopathologic features. Rare TFEB‐amplified RCCs have been described recently and are associated with a more aggressive clinical course. Herein, we report a case of an 86‐year‐old man with a solid 9.2‐cm kidney tumor
Ruihe Lin, Elizaveta Flerova, Christine E. Wamsley, Peter A. McCue, Costas D. Lallas, Wei Jiang, Jialing Huang, Zi‐Xuan Wang, Li Li   +8 more
wiley   +1 more source

Renal cell carcinoma associated with Xp11.2 translocation/transcription factor E3 gene fusion: an adult case report and literature review

Journal of International Medical Research, 2020
Renal cell carcinoma (RCC) associated with Xp11.2 translocation/transcription factor E3 ( TFE3 ) gene fusion is a rare and independent subtype of RCC included in the classification of MiT (microphthalmia-associated transcriptional factor) family ...
Yuxiong Wang, Yuantao Wang, Mingliang Feng, Xin Lian, Yongsheng Lei, Honglan Zhou   +5 more
doaj   +1 more source

A novel VCP::TFE3 gene fusion resulting from t(X;9)(p11.23;p13.3) chromosome translocation in TFE3 rearranged renal cancer cell carcinoma

Genes, Chromosomes and Cancer, Volume 62, Issue 6, Page 361-366, June 2023., 2023
Abstract Renal cell carcinoma (RCC) with rearrangement of transcription factor for immunoglobulin heavy‐chain enhancer 3 (TFE3; TFE3‐rearranged RCC) at Xp11.2 is a rare tumor entity but the most frequent among the microphthalmia transcription factor family translocation RCCs.
Marie Auvray Kuentz, Hélène Blons, Anne Paule Gimenez‐Roqueplo, Pierre‐Alexandre Just, Pierre Laurent‐Puig, Arnaud Mejean, Stéphane Oudard, Virginie Verkarre   +7 more
wiley   +1 more source

Tumor biology, biomarkers, and liquid biopsy in pediatric renal tumors

Pediatric Blood &Cancer, Volume 70, Issue S2, May 2023., 2023
Abstract The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new possibilities for diagnosis and treatment.
Amy L. Walz, Mariana Maschietto, Brian Crompton, Nicholas Evageliou, David Dix, Godelieve Tytgat, Manfred Gessler, David Gisselsson, Najat C. Daw, Jenny Wegert   +9 more
wiley   +1 more source

An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles

Journal of Extracellular Vesicles, Volume 12, Issue 2, February 2023., 2023
Abstract Extracellular vesicles (EV) are membranous particles secreted by all cells and found in body fluids. Established EV contents include a variety of RNA species, proteins, lipids and metabolites that are considered to reflect the physiological status of their parental cells.
Karina Barreiro, Abigail C. Lay, German Leparc, Van Du T. Tran, Marcel Rosler, Lusyan Dayalan, Frederic Burdet, Mark Ibberson, Richard J. M. Coward, Tobias B. Huber, Bernhard K. Krämer, Denis Delic, Harry Holthofer   +12 more
wiley   +1 more source

Case Report: Clinical complete response of advanced renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion by treated by camrelizumab and axitinib: A rare case report

Frontiers in Pharmacology, 2022
Renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusions is a rare subtype of renal tumor. This entity predominantly occurs in juveniles, but rarely in adults.
Juping Zhao, Kun Dai, Jialing Xie, Chen Fang, Na Chen, Jun Dai, Danfeng Xu   +6 more
doaj   +1 more source

PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. [PDF]

PLoS ONE, 2017
PRCC-TFE3 renal cell carcinoma (RCC) is one of the most common types of Xp11.2 translocation renal cell carcinoma (tRCC), of which the diagnosis mainly relies on reverse transcription-polymerase chain reaction (RT-PCR) or chromosomal analysis in fresh ...
Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan, Dongmei Li, Hongqian Guo   +7 more
doaj   +1 more source

The preliminary experiences of translocation renal cell carcinoma and literature review

Kaohsiung Journal of Medical Sciences, 2014
Xp11.2 translocation renal cell carcinoma (RCC) is rare and predominantly found in children and young adults. Because of the property of overexpressed transcription factor E3 (TFE3) fusion protein, immunohistochemical (IHC) staining with TFE3 antibody ...
Hsin-Hao Su, Ming-Tse Sung, Po-Hui Chiang, Yunan-Tso Cheng, Yen-Ta Chen   +4 more
doaj   +1 more source

Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma

Frontiers in Oncology, 2022
BackgroundThis study aimed to investigate the expression profile of TFE3 in renal cell carcinoma (RCC) and the clinicopathological features as well as prognosis of TFE3-positive RCC.MethodsTissue sections from 796 patients with RCC were collected for ...
Xiang Dong, Yuxin Chen, Jun Pan, Wenliang Ma, Peng Zhou, Ming Chen, Hongqian Guo, Weidong Gan   +7 more
doaj   +1 more source

The incidence of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in Saudi adult patients with renal cancer: a retrospective tissue microarray analysis

Polish Journal of Pathology, 2019
Renal cell carcinoma (RCC) is the most common renal tumour. RCC with Xp11.2 translocation/TFE3 (transcription factor E3) gene fusions (Xp11.2 RCC) is positive for immunostain labelling by TFE3 antibody. This tumour is rarely described in adults.
Jaudah Al-Maghrabi, Shagufta Mufti, Wafaey Gomaa   +2 more
doaj   +1 more source