Results 1 to 10 of about 673 (120)

Clinical and pathological heterogeneity of four common fusion subtypes in Xp11.2 translocation renal cell carcinoma [PDF]

Frontiers in Oncology, 2023
BackgroundXp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) is a group of rare and highly heterogeneous renal cell carcinoma (RCC). The translocation involving TFE3 and different fusion partners lead to overexpression of the chimeric protein.
Wei Guo, Wei Guo, Yiqi Zhu, Xiaohong Pu, Hongqian Guo, Weidong Gan, Weidong Gan   +6 more
doaj   +4 more sources

A new risk-scoring system to predict Xp11.2 translocation renal cell carcinoma in adults [PDF]

Journal of International Medical Research, 2021
Objective The objective was to derive and validate a practical scoring system for preoperative diagnosis of Xp11.2 translocation renal cell carcinoma (RCC) in adults.
Qiancheng Shi, Ning Liu, Yiqi Zhu, Feng Qu, Linfeng Xu, Xiaogong Li, Gutian Zhang, Hongqian Guo, Dongmei Li, Weidong Gan   +9 more
doaj   +3 more sources

Estrogen associates with female predominance in Xp11.2 translocation renal cell carcinoma [PDF]

Scientific Reports, 2023
Based on the epidemiological characteristics of susceptibility and age selectivity for women in Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC), we inferred that estrogen was to be blamed. Rad54 like 2 (Rad54l2) which might be one of key effector
Yanwen Lu, Yiqi Zhu, Wenliang Ma, Ning Liu, Xiang Dong, Qiancheng Shi, Fei Yu, Hongqian Guo, Dongmei Li, Weidong Gan   +9 more
doaj   +2 more sources

Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma [PDF]

Clinical and Translational Medicine, 2022
Background The aggressiveness of renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 translocation RCC [Xp11.2 tRCC]) is age‐dependent, which is similar to the overall trend of reproductive endocrine hormones ...
Ning Liu, Yi Chen, Lei Yang, Qiancheng Shi, Yanwen Lu, Wenliang Ma, Xiaodong Han, Hongqian Guo, Dongmei Li,, Weidong Gan,   +9 more
doaj   +2 more sources

Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma [PDF]

Cell Communication and Signaling, 2021
Background Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (TFE3) gene located on chromosome Xp11.2.
Qiancheng Shi, Ning Liu, Lei Yang, Yi Chen, Yanwen Lu, Hongqian Guo, Xiaodong Han, Dongmei Li, Weidong Gan   +8 more
doaj   +2 more sources

Gene Expression Analysis of Aggressive Adult Xp11.2 Translocation Renal Cell Carcinoma at Clinical Stage T1N0M0 to Identify Potential Prognostic and Therapeutic Biomarkers [PDF]

Biomedicines, 2022
Xp11.2 translocation renal cell carcinoma (tRCC), involving transcription factor E3 (TFE3) gene fusions, is a rare and aggressive RCC variant when present in adults and has been recently recognized as a unique entity in RCC.
Jee Soo Park, Myung Eun Lee, Won Sik Jang, Jongchan Kim, Se Mi Park, Won Sik Ham   +5 more
doaj   +2 more sources

Are tumor-associated micro-angiogenesis and lymphangiogenesis considered as the novel prognostic factors for patients with Xp11.2 translocation renal cell carcinoma? [PDF]

BMC Cancer, 2020
Background Tumor micro-angiogenesis and lymphangiogenesis are effective prognostic predictors in many solid malignancies. However, its role on Xp11.2 translocation RCC has not been fully elucidated.
Wenliang Ma, Jun Yang, Ning Liu, Xiaohong Pu, Feng Qu, Linfeng Xu, Xiaozhi Zhao, Xiaogong Li, Gutian Zhang, Hongqian Guo, Dongmei Li, Weidong Gan   +11 more
doaj   +2 more sources

Bilateral Xp11.2 translocation renal cell carcinoma: a case report [PDF]

BMC Urology, 2018
Background Xp11.2 translocation renal cell carcinoma (RCC) is a rare variety of a kidney neoplasm. We report a case of bilateral Xp11.2 translocation RCC occurring metachronously and discuss this very rare entity with reference to the literature.
Takashi Karashima, Takahira Kuno, Naoto Kuroda, Hirofumi Satake, Satoshi Fukata, Masakazu Chikazawa, Chiaki Kawada, Ichiro Yamasaki, Taro Shuin, Makoto Hiroi, Keiji Inoue   +10 more
doaj   +2 more sources

Molecular Heterogeneity of Xp11.2 Translocation Renal Cell Carcinoma: The Correlation Between Split Signal Pattern in FISH and Prognosis [PDF]

Cancer Management and Research, 2021
Yiqi Zhu,1,* Xiaohong Pu,2,* Xiang Dong,3 Changwei Ji,1 Hongqian Guo,1 Dongmei Li,4,5 Xiaozhi Zhao,1 Weidong Gan1 1Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People ...
Zhu Y, Pu X, Dong X, Ji C, Guo H, Li D, Zhao X, Gan W   +7 more
doaj   +2 more sources

Xp11.2 Translocation Renal Cell Carcinoma With TFE3 Rearrangement: Distinct Morphological Features and Prognosis With Different Fusion Partners [PDF]

Frontiers in Oncology, 2021
BackgroundRenal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion is a rare and new subtype of RCC and was classified by the WHO in 2004. Since then, multiple 5′ fusion partners for TFE3 have been reported; however, the impact of
Yan Ge, Xingtao Lin, Qingling Zhang, Danyi Lin, Luqiao Luo, Huiling Wang, Zhi Li   +6 more
doaj   +2 more sources