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Correction to "ARF induction in response to DNA strand breaks is regulated by PARP1". [PDF]
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XRCC1 keeps DNA from getting stranded
Mutation Research DNA Repair, 2000Larry H Thompson, L H Thompson
exaly +3 more sources
Polymorphic Study of XRCC1 G28152A and XRCC1 C26304T in 10 Chinese Populations
Biochemical Genetics, 2008Human cancer can be initiated by DNA damage caused by UV, ionizing radiation, and environmental chemical agents (Gundy 2006). To safeguard the integrity of genomes, humans have developed a set of complex DNA repair systems. Among the five main DNA maintenance mechanisms operating in mammals, base excision repair is the primary guardian against damage ...
Chao, Wang +5 more
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XRCC1 Arg194Trp polymorphism and thyroid cancer
Journal of Endocrinological Investigation, 2019Previously published data on the association between the XRCC1 Arg194Trp polymorphism and thyroid cancer (TC) remain controversial.To clarify the association between the XRCC1 Arg194Trp polymorphism and susceptibility to TC, a meta-analysis of case-control studies was conducted.
S-Y, Liu, W, Xue
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XRCC1 polymorphisms and head and neck cancer
Cancer Letters, 2002Inter-individual differences in DNA repair capacity have been demonstrated using a variety of phenotypic assays, including reduced repair among patients with squamous cell carcinoma of the head and neck (SCCHN). The XRCC1 DNA repair gene may facilitate DNA strand break and base excision repair. A recent case-control study of SCCHN reported associations
Andrew F, Olshan +3 more
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Association of XRCC1 polymorphisms with arsenic methylation
Archives of Toxicology, 2015The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100).
Junko, Fujihara +4 more
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XRCC1 gene polymorphisms and risk of ameloblastoma
Archives of Oral Biology, 2013Ameloblastoma is a common benign odontogenic tumour with inherently aggressive behaviour. Genetic susceptibility of single nucleotide polymorphism (SNP) can likely predict ameloblastoma at risk patients but this data remains limited. Here, we studied XRCC1 polymorphism as a risk factor for ameloblastoma.Eighty-two ameloblastoma samples and blood from ...
Pattamawadee, Yanatatsaneejit +3 more
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XRCC1 protein; Form and function
DNA Repair, 2019The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental analysis of this fascinating protein is still unveiling new insights into the DNA damage response. XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) including DNA kinase, DNA phosphatase ...
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XRCC1 and DNA strand break repair
DNA Repair, 2003DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base excision repair, or directly from damage to deoxyribose. Because single-strand breaks are induced by endogenous reactive molecules such as reactive oxygen species, these lesions pose a continuous threat to genetic integrity.
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XRCC1polymorphism and lung cancer risk
Expert Review of Molecular Diagnostics, 2008DNA repair plays a critical role in protecting the genome of the cell from the insults of carcinogens or ionizing radiation. Reduced DNA repair capacity can increase the susceptibility to environmental- or occupational-induced cancers. Three coding polymorphisms at codon 194, codon 280 and codon 399 in the x-ray cross complementing group 1 (XRCC1) DNA ...
Joachim, Schneider +2 more
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