Results 71 to 80 of about 7,729 (176)

Environmental Transformation and Trophic Transfer of Engineered Nanomaterials in the Agri‐Food Chain and Implications for human Health

ChemFoodChem, Volume 2, Issue 2, June 2026.
ABSTRACT Engineered nanomaterials (ENMs) are increasingly applied in agriculture to improve crop yield, nutrient efficiency, and food quality. This study examines the environmental transformation of ENMs, their uptake in plants, and their transfer across the agri‐food chain leading to human exposure.
Soumitra Nath
wiley   +1 more source

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li, Yan Shang, Haojie Wu, Shenglong Yang, Maiqun Zuo, Hailong Zhao   +5 more
wiley   +1 more source

The association of XRCC1 polymorphism with osteosarcoma risk, clinicopathologic features, and prognosis in a Chinese Han population

Cancer Management and Research, 2018
Ying-Guang Wu,1 Hong-Fu Li,2 Yan-Jun Ren,1 De-Bo Zou,1 Kai-Ning Zhang,1 Xing Xiao1 1Department of Spine Surgery, Qianfoshan Hospital, Shandong University, Jinan, Shandong, China; 2Department of Orthopedics, Second Hospital of Haibei Tibetan Autonomous ...
Wu YG, Li HF, Ren YJ, Zou DB, Zhang KN, Xiao X   +5 more
doaj  

Association Studies Between XRCC1, XRCC2, XRCC3 Polymorphisms and Differentiated Thyroid Carcinoma

Cellular Physiology and Biochemistry, 2016
Background/Aims: DNA HRR pathway and BER pathway play vital roles in differentiated thyroid cancer (DTC) development, thus we supposed that polymorphisms of XRCC1, XRCC2, XRCC3 DNA repair genes are associated with thyroid cancer risk and progression ...
Li Yan, Qinghuai Li, Xiaoyu Li, Hong Ji, Linlei Zhang   +4 more
doaj   +1 more source

Distribution and Haplotype Associations of XPD Lys751Gln, XRCC1 Arg280His and XRCC1 Arg399Gln Polymorphisms with Nasopharyngeal Carcinoma in the Malaysian Population

Asian Pacific Journal of Cancer Prevention, 2014
DNA repair pathways play a crucial role in maintaining the human genome. Previous studies associated DNA repair gene polymorphisms (XPD Lys751Gln, XRCC1 Arg280His and XRCC1 Arg399Gln) with nasopharyngeal carcinoma. These non-synonymous polymorphisms may alter DNA repair capacity and thus increase or decrease susceptibility.
Visuvanathan, Shaneeta, Chong, Pei Pei, Yap, Yoke Yeow, Lim, Chin Chye, Tan, Meng Khuan, Lye, Munn Sann   +5 more
openaire   +3 more sources

XRCC1 codon 399Gln polymorphism is associated with radiotherapy-induced acute dermatitis and mucositis in nasopharyngeal carcinoma patients

Radiation Oncology, 2013
Background To evaluate the association between single nucleotide polymorphisms (SNPs) at the 194 and 399 codons of XRCC1, and the risk of severe acute skin and oral mucosa reactions in nasopharyngeal carcinoma patients in China. Methods 114 patients with
Li Haijun, You Yanjie, Lin Canfeng, Zheng Mingzhang, Hong Chaoqun, Chen Jiongyu, Li Derui, Au William W, Chen Zhijian   +8 more
doaj   +1 more source

Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma

BMC Cancer, 2009
Background Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2), and X-ray repair cross-complementing group 1 (XRCC1) proteins play important roles in the repair of DNA damage and adducts.
Su Meng, Xue Xiaoxia, Cui Zeshi, Li Xuelian, Guan Peng, Li Mingchuan, He Qincheng, Zhou Baosen, Yin Zhihua, Ma Rui, Bai Weijun, Xia Shuyue, Jiang Yanduo, Xu Shun, Lv Yi, Li Xun   +15 more
doaj   +1 more source

Preliminary Study on the Single Nucleotide Polymorphism (SNP) of XRCC1 Gene Identificationto Improve the Outcomes of Radiotherapy for Cervical Cancer

Biosaintifika: Journal of Biology & Biology Education, 2015
Cervical cancer is the most fatal disease among Indonesian women. In recognition of the substantial variation in the intrinsic response of individuals to radiation, an effort had been done to identify the genetic markers, primarily Single Nucleotide ...
Devita Tetriana, Wiwin Mailana, Iin Kurnia, Mukh Syaifudin   +3 more
doaj   +1 more source

XRCC1 Arg399Gln and Arg194Trp polymorphisms regulate XRCC1 expression and chemoresistance of non-small cell lung cancer cells

BIOCELL, 2019
X-ray repair cross-complementing protein 1 (XRCC1) could repair cisplatin-induced DNA damage. XRCC1 Arg399Gln and Arg194Trp variants alter XRCC1 expression and function, leading to changes in cancer sensitivity to cisplatin treatment. This study aimed to investigate the effects of XRCC1 Arg399Gln and Arg194Trp polymorphisms on cell viability, apoptosis
Dairong LI, Xianlu ZHUO, Lumi HUANG, Xiaohui JI, Donglin WANG   +4 more
openaire   +1 more source

XRCC1 deficiency drives telomeric chromatin leakage, inflammatory signalling and senescence

Redox Biology
Genome integrity is constantly challenged by oxidative DNA damage, which, if left unrepaired, can result in replication stress, chromosomal instability, and tumorigenesis.
Anna Piscone, Francesca Gorini, Susanna Ambrosio, Carmen Caiazza, Giannicola Marotta, Anna Noviello, Giovanni Di Fusco, Giovanni Scala, Barbara Majello, Stefano Amente   +9 more
doaj   +1 more source