Results 61 to 70 of about 7,729 (176)

Association of X-ray repair cross complementing group 1 Arg399Gln polymorphisms with the risk of squamous cell carcinoma of the head and neck: evidence from an updated meta-analysis. [PDF]

PLoS ONE, 2013
BACKGROUND: Epidemiologic studies have reported the association of X-ray repair cross-complementary group 1 (XRCC1) Arg399Gln polymorphisms with susceptibility to squamous cell carcinoma of the head and neck (HNSCC). However, the results were conflictive
Yadong Wang, Xinwei Chu, Xiaojing Meng, Fei Zou   +3 more
doaj   +1 more source

Arabidopsis DNA repair mutants can integrate Agrobacterium T‐DNA into the plant genome

New Phytologist, Volume 251, Issue 4, Page 1811-1822, August 2026.
Transient (a) and stable (b) transformation of Arabidopsis thaliana DNA repair/recombination mutants grown under normal light conditions. Summary Agrobacterium transfer DNA (T‐DNA) integration is mediated by plant DNA repair proteins of various nonhomologous end‐joining (NHEJ) pathways.
Lan‐Ying Lee, Yunjia Shen, Yooyoung Kim, Ayako Nishizawa‐Yokoi, Hiroaki Saika, Demi White, Wenying Liao, Stanton B. Gelvin   +7 more
wiley   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Association between the XRCC1 polymorphisms and clinical outcomes of advanced NSCLC treated with platinum-based chemotherapy: a meta-analysis based on the PRISMA statement

BMC Cancer, 2017
Background Base excision repair (BER) pathway is a DNA repair pathway that is important in carcinogenesis and in response to DNA-damaging chemotherapy. XRCC1 is one of important molecular markers for BER.
Dan-Juan Li, Dong Xiao
doaj   +1 more source

XRCC1 Arg399Gln Genetic Polymorphism in a Turkish Population [PDF]

International Journal of Toxicology, 2006
Humans are routinely exposed to mutagenic and carcinogenic chemicals. These chemicals can form DNA adducts in vivo and thus lead to DNA damage. The integrity of most of the so-damaged DNAs is typically restored as a consequence of the action of certain DNA-repairing enzymes.
Karahalil, BENSU, Kocabas, Neslihan Ayguen   +1 more
openaire   +3 more sources

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam, Anas Shamsi, Syed Tasqeruddin, Moyad Shahwan   +3 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The association between polymorphism XRCC1 (rs25487) and the susceptibility of chemical industry workers to benzene [PDF]

Journal of Advanced Biomedical Sciences, 2018
Background & Objective: Benzene, as a carcinogenic compound, can damage DNA by producing free oxygen radicals. Benzene effects have been reported in the blood system.
Negar Musavi, Farzaneh Tafvizi, Yaser Mansoori   +2 more
doaj  

XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib

Therapeutic Advances in Medical Oncology, 2020
Background: PARP inhibitor (PARPi) monotherapy is a new strategy in BRCA germ-line deficient triple negative breast cancer (TNBC). However, not all patients respond, and the development of resistance limits the use of PARPi monotherapy.
Reem Ali, Adel Alblihy, Michael S. Toss, Mashael Algethami, Rabab Al Sunni, Andrew R. Green, Emad A. Rakha, Srinivasan Madhusudan   +7 more
doaj   +1 more source

Association of XRCC1 polymorphisms with thyroid cancer risk

Tumor Biology, 2014
Due to the important role in the DNA repair pathways, numerous studies have been carried out to explore the relationship between the polymorphisms in the X-ray repair cross-complementing group 1 (XRCC1) gene and thyroid cancer risk. But previous reports have produced conflicting results.
Cong, Wang, Zhilong, Ai
openaire   +2 more sources