Results 41 to 50 of about 7,729 (176)

Structural and Functional Analysis of DNA-repair Gene Variants (XRCC1, ERCC2/XPD) and their Relevance to Chronic Kidney Disease Pathogenesis [PDF]

Al-Anbar Medical Journal
Background: According to statistics, chronic kidney disease (CKD) is the fourth leading cause of death in the world and its rate of 4.32% of total deaths in Iraq.
Fahad Abo-Ghneim, Dhafer Al-Koofee, Hussain Mohammed   +2 more
doaj   +1 more source

Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. [PDF]

PLoS ONE, 2014
BACKGROUND: Previous studies on the association of X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg399Gln, and Arg280His polymorphisms with head and neck cancer (HNC) have produced inconsistent results.
Wei Wu, Lu Liu, Zhihua Yin, Peng Guan, Xuelian Li, Baosen Zhou   +5 more
doaj   +1 more source

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia [PDF]

Nature, 2016
XRCC1 is a molecular scaffold protein that assembles multi-protein complexes involved in DNA single-strand break repair. Here we show that biallelic mutations in the human XRCC1 gene are associated with ocular motor apraxia, axonal neuropathy, and progressive cerebellar ataxia.
Hoch, Nicolas C, Hanzlikova, Hana, Rulten, Stuart L, Tétreault, Martine, Komulainen, Emilia, Ju, Limei, Hornyak, Peter, Zeng, Zhihong, Gittens, William, Rey, Stephanie A, Staras, Kevin, Mancini, Grazia M S, McKinnon, Peter J, Wang, Zhao-Qi, Wagner, Justin D, Care4Rare Canada Consortium, , Yoon, Grace, Caldecott, Keith W   +17 more
openaire   +2 more sources

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk

Clinical and Experimental Gastroenterology, 2020
Jagjeet Kaur, 1 Vasudha Sambyal, 1 Kamlesh Guleria, 1 Neeti Rajan Singh, 2 Manjit Singh Uppal, 2 Mridu Manjari, 3 Meena Sudan 4 1Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar, India; 2Department of ...
Kaur J, Sambyal V, Guleria K, Singh NR, Uppal MS, Manjari M, Sudan M   +6 more
doaj  

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Association between XRCC1 (rs1799782) Gene Polymorphism and Oral squamous cell carcinoma

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Oral squamous cell carcinoma (OSCC) is the most common tumor of the head and neck. XRCC1 is a DNA repair gene and there are controversies about the association between XRCC1 gene polymorphism (RS1799782) in pathogenesis and ...
Safoura Seifi, Mohammad-Hossein Mosaedi, Abbas Mohahammadpour, Hamid Reza Nouri, Ali Bijani   +4 more
doaj  

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Are Ocular Markers of Sun Exposure Associated With Skin Cancer? A Cross‐Sectional Analysis of the Busselton Healthy Ageing Study

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Higher past sun or ultraviolet radiation exposure increases the risk of skin cancer and three common ocular findings: pterygium, conjunctival ultraviolet autofluorescence (CUVAF) and myopia. We investigated whether ocular markers of past sun exposure are associated with a history of skin cancer.
Gareth Lingham, Vinay Kumar Nilagiri, Holly Brown, Chrianna Bharat, Samantha S. Y. Lee, Maria Franchina, Michael Hunter, Kevin Murray, David Alonso‐Caneiro, Catherine M. Olsen, David C. Whiteman, David A. Mackey   +11 more
wiley   +1 more source