Results 31 to 40 of about 7,729 (176)

The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females

BMC Cancer, 2017
Background The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro
Jainagul Isakova, Elnura Talaibekova, Nazira Aldasheva, Denis Vinnikov, Almaz Aldashev   +4 more
doaj   +1 more source

XRCC1 co-localizes and physically interacts with PCNA [PDF]

Nucleic Acids Research, 2004
X-ray Repair Cross Complementing 1 (XRCC1) is thought to function as a scaffolding protein in both base excision repair and single-strand break repair (SSBR), since it interacts with several proteins participating in these related pathways and has no known enzymatic activity.
Jinshui, Fan, Marit, Otterlei, Heng-Kuan, Wong, Alan E, Tomkinson, David M, Wilson   +4 more
openaire   +2 more sources

X-ray repair cross-complementing protein 1 (XRCC1) loss promotes β-lapachone –induced apoptosis in pancreatic cancer cells

BMC Cancer, 2021
Background β-lapachone (β-lap), the NQO1 bioactivatable drug, is thought to be a promising anticancer agent. However, the toxic side effects of β-lap limit the drug use, highlighting the need for a thorough understanding of β-lap’s mechanism of action. β-
Yansong Zheng, Hengce Zhang, Yueting Guo, Yuan Chen, Hanglong Chen, Yingchun Liu   +5 more
doaj   +1 more source

XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk [PDF]

Carcinogenesis, 2007
DNA damage is important in the pathogenesis of esophageal adenocarcinoma (EA). Polymorphic variants in DNA repair genes may be modifiers of the risk of EA through their role in altering human host response to gastroesophageal acid reflux, a well-described risk factor for EA.
Geoffrey, Liu, Wei, Zhou, Beow Y, Yeap, Li, Su, John C, Wain, John M, Poneros, Norman S, Nishioka, Thomas J, Lynch, David C, Christiani   +8 more
openaire   +2 more sources

Association of XRCC1 Arg399GIn and Tp53 Arg72Pro polymorphisms and increased risk of uterine leiomyoma - A case-control study

Genetics and Molecular Biology, 2015
The aim of present study was to investigate the role of the X-ray repair cross-complementing protein1 (XRCC1) and Tumor protein p53 (Tp53) polymorphisms in Uterine Leiomyoma (UL) susceptibility in southeastern Iran.
Minoo Yaghmaei, Saeedeh Salimi, Lida Namazi, Farzaneh Farajian-Mashhadi   +3 more
doaj   +1 more source

Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis

Cell Reports, 2021
Summary: Assembly and disassembly of DNA repair protein complexes at DNA damage sites are essential for maintaining genomic integrity. Investigating factors coordinating assembly of the base excision repair (BER) proteins DNA polymerase β (Polβ) and ...
Christopher A. Koczor, Kate M. Saville, Joel F. Andrews, Jennifer Clark, Qingming Fang, Jianfeng Li, Rasha Q. Al-Rahahleh, Md Ibrahim, Steven McClellan, Mikhail V. Makarov, Marie E. Migaud, Robert W. Sobol   +11 more
doaj   +1 more source

Tumor site- and stage-specific associations between allelic variants of glutathione S-transferase and DNA-repair genes and overall survival in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. [PDF]

PLoS ONE, 2013
INTRODUCTION: Our retrospective cohort study investigated the effect of tumor site and stage on the associations between the allelic variants of glutathione S-transferase (GST) and DNA-repair genes and overall survival (OS) in CRC patients treated with 5-
Ching-Yu Lai, Ling-Ling Hsieh, Fung-Chang Sung, Reiping Tang, Chyi-Huey Bai, Fang-Yang Wu, Hung-Yi Chiou, Chih-Ching Yeh   +7 more
doaj   +1 more source

XRCC1 399^*Arg-related genotype and allele, but not XRCC1 His107Arg, XRCC1 Trp194Arg, KCNQ2, AT1R, and hOGG1 polymorphisms, are associated with higher susceptibility of endometriosis

Gynecological Endocrinology, 2011
X-ray repair cross-complementing group 1 (XRCC1) and human 8-oxoguanine glycosylase 1 (hOGG1) play important roles in base excision repair. KCNQ genes comprising voltage-gated ion-channels related with cell stability. Angiotensin II type 1 receptor (AT1R) is related with angiogenesis, which influence endometriosis growth, invasion and regression.
Yao-Yuan, Hsieh, Chi-Chen, Chang, Shih-Yin, Chen, Chih-Ping, Chen, Wen-Hsin, Lin, Fuu-Jen, Tsai   +5 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source