Results 11 to 20 of about 7,729 (176)
XRCC1 Polymorphisms and Urinary 8-Hydroxydeoxyguanine Levels Are Associated with Urothelial Carcinoma. [PDF]
PLoS ONE, 2015 The aim of this study was to examine the associations between the combined effects of urinary 8-Hydroxydeoxyguanine (8-OHdG) level and polymorphisms of XRCC1 Arg194Trp and XRCC1 Arg399Gln on the risk of urothelial carcinoma (UC).
Chien-I Chiang +7 more
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XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer
Frontiers in Molecular Biosciences, 2020 Gallbladder cancer is a relatively uncommon human malignant tumor with an extremely poor prognosis. Currently, no biomarkers can accurately diagnose gallbladder cancer and predict patients’ prognosis.
Zhengchun Wu +7 more
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Frontiers in Genetics, 2023 Background: Epidemiologic studies have demonstrated that X-ray repair cross-complementary group 1 (XRCC1) is one of the susceptibility factors in head and neck squamous cell carcinoma (HNSCC) patients.
Fan Yang +4 more
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Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma [PDF]
Archives of Razi Institute, 2023 Gastric cancer (GC) is one of the deadliest tumors due to its competence to invade and metastasize. The DNA repair gene (XRCC1), interleukin-8 (IL-8) gene, and B-cell lymphoma 2 (Bcl-2) gene play a crucial role in the development and progression of GC ...
D Auni Kamal +2 more
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The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function [PDF]
Nucleic Acids Research, 2015 Poly (ADP-ribose) is synthesized at DNA single-strand breaks and can promote the recruitment of the scaffold protein, XRCC1. However, the mechanism and importance of this process has been challenged. To address this issue, we have characterized the mechanism of poly (ADP-ribose) binding by XRCC1 and examined its importance for XRCC1 function.
Breslin, Claire +6 more
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Disconnecting XRCC1 and DNA ligase III [PDF]
Cell Cycle, 2011 DNA strand break repair is essential for the prevention of multiple human diseases, particularly those which feature neuropathology. To further understand the pathogenesis of these syndromes, we recently developed animal models in which the DNA single-strand break repair (SSBR) components, XRCC1 and DNA Ligase III (LIG3), were inactivated in the ...
Sachin, Katyal, Peter J, McKinnon
openaire +2 more sources
International Journal of Occupational Medicine and Environmental Health, 2022 Objectives Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes ( XRCC1 , OGG1 and MUTYH ) and level of ...
Jacek Kabziński, Ireneusz Majsterek
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DNA repair gene XRCC1 polymorphisms and head and neck cancer risk: an updated meta-analysis including 16344 subjects. [PDF]
PLoS ONE, 2013 BACKGROUND: DNA repair gene X-ray repair cross complementing group 1 (XRCC1) plays an important role in the maintenance of the genomic integrity and protection of cells from DNA damage. Sequence variation in XRCC1 gene may alter head and neck cancer (HNC)
Yin Lou +5 more
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PLoS ONE, 2013 IntroductionAtaxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair.
Rebeka Sultana +8 more
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Breast Cancer Susceptibility Gene in Base Excision Repair Pathway in a Southern Indian Population [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Breast cancer, the most complex multifactorial disease, one of the most common malignancies seen in females over the world. Single-Nucleotide Polymorphisms (SNPs) that occur in DNA repair genes are the contributors to cancer development as ...
Andrea Mary Francis +6 more
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