Results 21 to 30 of about 7,729 (176)
PLoS ONE, 2019 DNA repair defects have been increasingly focused on as therapeutic targets. In hormone-positive breast cancer, XRCC1-deficient tumors have been identified and proposed as targets for combination therapies that damage DNA and inhibit DNA repair pathways.
Kevin J Lee +5 more
doaj +1 more source
Impact of polymorphisms in base excision repair genes on seminal fluid parameters [PDF]
Exploration of MedicineAim: Abnormalities in sperm parameters can result from genetic variations in DNA repair genes. The base excision repair (BER) pathway is responsible for maintaining DNA integrity.
Mahmoud A. Hassouna +4 more
doaj +1 more source
Scientific Reports, 2017 XRCC1 is a scaffold protein involved in base excision repair and single strand break repair. It is a phosphoprotein that contains more than 45 phosphorylation sites, however only a few of these have been characterized and connected to specific kinases ...
Mirta Mittelstedt Leal de Sousa +4 more
doaj +1 more source
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: Inflammation-promoting exposures, including hyperglycemia and inflammatory cytokines, are common in the development and progression of multiple cancers.
Natalie R Gassman +2 more
doaj +1 more source
XRCC1 polymorphisms and pancreatic cancer: A meta-analysis [PDF]
Chinese Journal of Cancer Research, 2011 To assess the association between X-ray repair cross-complementating group 1 (XRCC1) polymorphisms and pancreatic cancer.We searched MEDLINE, Web of Science and HuGE Navigator at June 2010, and then quantitatively summarized associations of the XRCC1 polymorphisms with pancreatic cancer risk using meta-analysis.Four studies with 1343 cases and 2302 ...
Wei-Dong, Shen +2 more
openaire +2 more sources
Chinese Journal of Lung Cancer, 2011 Background and objective DNA repair gene polymorphisms can be used to predict the sensitivity of platinum-based chemotherapy. Thus, such polymorphisms are important for the individual treatment of non-small cell lung cancer (NSCLC). The aim of this study
Chong’an XU +3 more
doaj +1 more source
Middle East Journal of Digestive Diseases, 2018 BACKGROUND The association between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln gene polymorphism and hepatocellular carcinoma (HCC) has been investigated in several populations. However, the findings are controversial.
Afsaneh Bazgir +3 more
doaj +1 more source
Middle East Journal of Cancer, 2020 Background: Genomic polymorphisms of DNA repair enzymes/excision repair cross complementation group 1 (ERCC1), excision repair cross complementation group 2 (ERCC2), and X-ray repair cross complementation group 1 (XRCC1) correlate with survival and ...
Kinjal Gajjar +3 more
doaj +1 more source
Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer [PDF]
International Journal of Molecular Sciences, 2021 Base Excision Repair (BER) addresses base lesions and abasic sites induced by exogenous and endogenous stressors. X-ray cross complementing group 1 (XRCC1) functions as a scaffold protein in BER and single-strand break repair (SSBR), facilitating and coordinating repair through its interaction with a host of critical repair proteins.
Griffin Wright +2 more
openaire +2 more sources
Journal of Experimental & Clinical Cancer Research, 2009 Background Platinum-based neoadjuvant chemotherapy (NAC) is new therapeutic strategy for locally advanced cervical carcinoma, but the variables used to predict NAC response are still infrequently reported.
Xie Xing +4 more
doaj +1 more source