Polymorphism of DNA repair genes XRCC1 280, XRCC1 194, XRCC1 339 and XPD 751 with stomach cancer
Бюллетень сибирской медицины, 2011 We evaluated the frequency distribution of polymorphic variants in DNA repair genes XRCC1 280, XRCC1 194, XRCC1 399 and XPD 751 gastric cancer patients and healthy controls, leading to new fundamental knowledge and molecular genetic markers of gastric ...
S. S. Rakitin +4 more
doaj +3 more sources
Domain analysis of PNKP–XRCC1 interactions: Influence of genetic variants of XRCC1 [PDF]
Journal of Biological Chemistry, 2019 Polynucleotide kinase/phosphatase (PNKP) and X-ray repair cross-complementing 1 (XRCC1) are key proteins in the single-strand DNA break repair pathway. Phosphorylated XRCC1 stimulates PNKP by binding to its forkhead-associated (FHA) domain, whereas nonphosphorylated XRCC1 stimulates PNKP by interacting with the PNKP catalytic domain.
Michael Weinfeld +2 more
exaly +3 more sources
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes [PDF]
DNA Repair, 2010 Uracil-DNA glycosylase, UNG2, interacts with PCNA and initiates post-replicative base excision repair (BER) of uracil in DNA. The DNA repair protein XRCC1 also co-localizes and physically interacts with PCNA. However, little is known about whether UNG2 and XRCC1 directly interact and participate in a same complex for repair of uracil in replication ...
Marit Otterlei +2 more
exaly +3 more sources
Loss of XRCC1 promotes cGAS/STING mediated innate immune signaling in gastric cancer [PDF]
Molecular MedicineBackground One of the most defining features of gastric cancer (GC) is harboring deficiency in DNA repair that subsequently contributes to carcinogenesis.
Aashirwad Shahi +3 more
doaj +2 more sources
The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1 [PDF]
DNA Repair, 2012 XRCC1 functions as a non-enzymatic, scaffold protein in single strand break repair (SSBR) and base excision repair (BER). Here, we examine different regions of XRCC1 for their contribution to the scaffolding functions of the protein. We found that the central BRCT1 domain is essential for recruitment of XRCC1 to sites of DNA damage and DNA replication.
Marit Otterlei, , Mansour Akbari
exaly +4 more sources
The structural basis of XRCC1-mediated DNA repair [PDF]
DNA Repair, 2015 Scaffold proteins play a central role in DNA repair by recruiting and organizing sets of enzymes required to perform multi-step repair processes. X-ray cross complementing group 1 protein (XRCC1) forms enzyme complexes optimized for single-strand break repair, but participates in other repair pathways as well.
Robert London
exaly +4 more sources
A meta-analysis and expression profiling of DNA repair gene polymorphisms in leukemia [PDF]
Frontiers in OncologyBackgroundGenetic susceptibility is believed to contribute to leukemia development. This study aimed to systematically evaluate the association between DNA repair gene polymorphisms, particularly xeroderma pigmentosum (XP) and excision repair cross ...
Honghui Ye, Jinyong Fang, Pei Jin
doaj +2 more sources
Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish [PDF]
Scientific ReportsDefects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1, a scaffold protein that plays a central role in DNA single-strand base repair ...
Svetlana A. Semenova +7 more
doaj +2 more sources
Associations between XRCC1-Arg399Gln polymorphism and the risk of prostate cancer: an updated meta-analysis [PDF]
Amino AcidsThe X-ray repair cross-complementary group 1 (XRCC1) gene 399 codon polymorphism may alter the structure of DNA repair enzymes to regulate DNA repair capacity.
Jiang Deng, Lihua Xu, Jun Zhou, He Huang
doaj +2 more sources
Fushe yanjiu yu fushe gongyi xuebao, 2023 This study investigated the effect of poly-ADP ribose polymerase inhibitor (PARPi) on X-ray repair cross complementing 1 gene (XRCC1) expression and radiotherapy sensitivity of esophageal squamous cell carcinoma (ESCC).
LI Yiping +5 more
doaj +1 more source