Results 151 to 160 of about 167,087,863 (243)

Uncovering Hidden Genetic Contributors to 46,XY Disorders of Sex Development Through Phenotype-Driven Rare Variant Assessment: A Pilot Study. [PDF]

Genes (Basel)
Tang Y, Chen Y, Zhang Q, Tang J, Ding Y, Li J, Yu T, Wang X.   +7 more
europepmc   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Gene-Dosage Effect of V89L Variants in Steroid 5α-Reductase Type 2 and Increased Risk of 46, XY Disorders of Sex Development: A Systematic Review and Meta-Analysis. [PDF]

J Indian Assoc Pediatr Surg
Deeba F, Choudhury P, Sharma J, Jain V, Dhua AK, Yadav DK, Singh H, Afroz M, Dhikav V, Kumar N, Pandey H, Lal D, Goel P.   +12 more
europepmc   +1 more source

Functional study of a novel c.630delG (p.Y211Tfs*85) mutation in NR5A1 gene in a Chinese boy with 46,XY disorders of sex development. [PDF]

J Assist Reprod Genet, 2020
Pan S, Guo S, Liu L, Yang X, Liang H.
europepmc   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, Volume 13, Issue 49, 3 September 2026.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

46, XY disorders of sex development combined with aceruloplasminaemia: a case report and review of the literature. [PDF]

Orphanet J Rare Dis
Li Y, Zhao M, Liu Y, Wang L, Huang Y, Wang F.   +5 more
europepmc   +1 more source

Heterogeneity in the association between cardiovascular disease and cognitive decline: a pooled analysis of five prospective cohort studies from 24 countries

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION We assessed the association between cardiovascular disease (CVD) and cognitive decline in adults aged 50 years or older using pooled data from five multinational cohorts, quantified heterogeneity, and explored its potential sources.
Juanjuan Li, Lili Cui, Yuan Xu, Yuyan Ding, Junhao Huo, Dongmei Niu, Hong Chen, Bo Kou, Jiangping Li, Liqun Wang   +9 more
wiley   +1 more source

The clinical diversity and molecular etiology in 46, XY disorders of sex development patients without uterus. [PDF]

Orphanet J Rare Dis
Ding L, Luo M, Deng S, Zhang D, Tian Q.
europepmc   +1 more source

Retinal microvascular changes are related to indicators of glymphatic dysfunction and small vessel disease in frontotemporal dementia

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Retinal vascular alterations have been associated with cerebral small vessel disease (SVD) in frontotemporal dementia (FTD), but their relationship with magnetic resonance imaging (MRI)‐derived glymphatic‐related diffusion markers remains unclear.
William Robert Kwapong, Yufei Chen, Xu Chen, Jiahui Hou, Hua Lu, Yuxuan Xu, Qianqian He, Yuan Gao, Ruoyu Jiao, Liyong Wu, Xuxiang Zhang, Min Chu   +11 more
wiley   +1 more source