Results 201 to 210 of about 167,087,863 (243)

Three-Year Experience of Cytogenetic and Molecular Genetic Evaluation in Patients With Disorders of Sex Development at a Tertiary Care Centre in Eastern India. [PDF]

Cureus
Sahoo S, Tripathy BB, Tripathy PR, Narayan RK, Kumar KP, Gaikwad MR.   +5 more
europepmc   +1 more source

Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties. The transcription factor Creb3l1 binds both gene promoters and drives their expression; its overexpression restores Col1a1 and Sparc levels and improves the gliding function, healing strength, and elastic modulus of ...
Qian Qian Yang, Zhanghao Huang, Yan Xue, Jia Yu Shi, You Lang Zhou   +4 more
wiley   +1 more source

Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex‐Specific Hepatic Transcriptional Changes at Single‐Cell Resolution

Aging Cell, Volume 25, Issue 9, September 2026.
Reducing growth hormone receptor signaling beginning in middle age is sufficient to extend lifespan in both sexes while preserving metabolic and physical function, particularly in males. Single‐nucleus RNA sequencing reveals sex‐specific hepatic transcriptional remodeling associated with these longevity benefits. ABSTRACT Suppression of growth hormone (
Silvana Duran‐Ortiz, Edward O. List, Jonathan A. Young, Yuji Ikeno, Shouan Zhu, Todd McHugh, Patrick M. O'Connor, Minhoo Kim, Bérénice A. Benayoun, Fabian Benencia, Reetobrata Basu, Emmanuel A. Gotte, Darlene E. Berryman, John J. Kopchick   +13 more
wiley   +1 more source

USP34 Haploinsufficiency as a Cause of Neurodevelopmental Phenotypes

Clinical Genetics, Volume 110, Issue 3, Page 315-324, September 2026.
Heterozygous loss‐of‐function variants in USP34 cause a novel neurodevelopmental disorder characterized by global developmental delay, speech impairment, autism, hypotonia, craniofacial dysmorphism, and distal limb anomalies. Disrupted Wnt/β‐catenin signaling via reduced Axin stabilization refines gene‐specific contributions within 2p15p16.1 ...
Helena Wigoda, Amjad Khan, Bryce A. Mendelsohn, Noriko Miyake, Nobuhiko Okamoto, Naomichi Matsumoto, Patricia J. C. Knijnenburg, Johanna M. van Hagen, Jiddeke van de Kamp, Quinten Waisfisz, Bryn D. Webb   +10 more
wiley   +1 more source

The Relationship Between Dysglycemia and Dyslipidemia in First‐Episode, Untreated Chinese Patients With Major Depressive Disorder at Different Ages of Onset

Early Intervention in Psychiatry, Volume 20, Issue 9, September 2026.
ABSTRACT Purpose Dysglycemia, a common ailment in MDD patients, lacks research regarding its variance across the age of onset (AOO). Therefore, we investigated the correlation between fasting blood glucose (FBG) abnormalities and blood lipids in first‐onset, untreated patients with MDD and to determine the factors that influence glycemic abnormalities ...
Hang Tan, Zhanjin Wang, Jie Ma, Zhan Wang, Xiang Yang Zhang   +4 more
wiley   +1 more source

Swyer syndrome complicated by rapidly progressive invasive ovarian dysgerminoma with bladder and rectal direct invasion: a rare case report. [PDF]

Front Oncol
Feng Y, Chen X, Xu Y, Xia M, Xie T, Yang R, Du K, Chen Y.   +7 more
europepmc   +1 more source

Single‐Cell Immune Profiling Suggests Non‐Classical Monocyte Is Associated Immunodepression in Tuberculosis Treatment Non‐Responders

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Sputum culture conversion (SCC) at 2 months is an early indicator of tuberculosis (TB) treatment response, yet the associated immune alterations remain incompletely defined. We performed single‐cell RNA sequencing on peripheral blood mononuclear cells from eight TB patients, stratified by 2‐month SCC status.
Yiqun Xiong, Yahong Qu, Ying Wang, Dongliang Zhang, Hao Shen, Weixin Wang, Junshun Gao, ZhenBo Wang, Zhihong Shen, Yang Che   +9 more
wiley   +1 more source

Beyond genital phenotype - Commentary on "Long-term outcomes in 45,X/46,XY mosaicism: a 30-year retrospective study in Hong Kong&quot. [PDF]

Ann Pediatr Endocrinol Metab
Jung SY.
europepmc   +1 more source