Results 91 to 100 of about 19,928 (247)

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Efficacy of “groundnut oil” and “coconut oil” as a substitute for “xylene” in clearing tissues samples – A comparative study

SRM Journal of Research in Dental Sciences, 2019
Background: Since yore, “xylene” has always been the nonpareil clearing medium known to be employed in tissue processing and staining. However, the toxic effects of “xylene” range from mild irritation to its severe form as a carcinogenic agent.
Priyadharshini Saravanakumar, R Bharanidharan, Ramya Ramadoss, Aravind, A Ramesh Kumar   +4 more
doaj   +1 more source

Highly solvent-dependent naphthalene diimide-based fluorescent polymer sensors for detecting p-xylene

P-xylene (PX), as one of xylenes, is a kind of very important chemical raw material. It is generally fabricated using methanol (MeOH) and toluene (TOL), and serves as a useful intermediary.
Rongjin Zeng (2590252), Yong Tian (1461202), Yubin Zhang (347822), Liqi Wu (611946), Hong Wang (13528), Zhihua Zhou (278990), Zhong Lin (801642), Jian Chen (15340)   +7 more
core   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Enhanced deep-blue emission from Pt(II) complexes bound to 2-pyridyltetrazolate and an ortho-xylene-linked bis(NHC)cyclophane

, 2013
The coordination of 2-pyridyltetrazolate and ortho-xylene-linked bis(NHC)cyclophane to Pt(II) yielded a novel complex characterised by enhanced pure deep-blue emission, whose intensity can be modulated via methylation of the tetrazole ...
S. Stagni (23305756), M. Baker (7679099), Karen McGee (20719003), Paolo Raiteri (1498624), S. Muzzioli (23305759), C. Siedlovskas (23424394), Massimiliano Massi (817332), Phillip Wright (3569426), David Brown (71846)   +8 more
core  

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Investigating the effect of gas flow rate, inlet ozone concentration and relative humidity on the efficacy of catalytic ozonation process in the removal of xylene from waste airstream

Salāmat-i kār-i Īrān, 2010
Background and aimsThe catalytic ozonation is an efficient process for the degradation of volatile organic compounds from contaminated air stream. This study was aimed at investigating the efficacy of catalytic ozonation process in removal of xylene from
H.R. MokaramI, A. Khavanin, Gh.R. Moussavi   +2 more
doaj  

Environmental risk limits for xylene (m-xylene, o-xylene and p-xylene)

, 2009
Het RIVM heeft milieurisicogrenzen afgeleid voor xylenen in water, grondwater en bodem. Deze stoffen worden gebruikt als oplosmiddel bij drukkerijen en in de rubberindustrie. De groep stoffen omvat m-xyleen, o-xyleen en p-xyleen. Voor dit onderzoek zijn actuele (eco)toxicologische gegevens gebruikt, gecombineerd met de meest recente methodiek.
openaire   +1 more source