Results 151 to 160 of about 436,984 (262)

Y-chromosome alteration and its impact on cancer progression and metastasis. [PDF]

Cell Mol Biol Lett
King SA, Jahan M, Prabhakaraalva P, Zaman N, Chaudhary S, Kyprianou N, Tewari AK, Chakraborty G.   +7 more
europepmc   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila. [PDF]

Mol Biol Evol
Fontan A, Lannes R, Fingerhut JM, Flynn JM, Yamashita YM.   +4 more
europepmc   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

OligoY pipeline for full Y chromosome painting. [PDF]

Brief Bioinform
Almeida I, Bruno HAB, Guimarães Dupim E, Santana Pinheiro MML, Carvalho AB, Vibranovski MD.   +5 more
europepmc   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes. [PDF]

Nat Med
Sato G, Yamamoto Y, Sonehara K, Saiki R, Ojima T, Kanai M, Liu A, Edahiro R, Shirai Y, Namba S, Namkoong H, Hasaegawa T, Koyanagi YN, Kasugai Y, Yamaji T, Nakano S, Genovese G, Sipilä TP, Ghazal A, Tanaka H, Azekawa S, Uwamino Y, Yamamoto K, Suzuki K, Hata T, Uemura M, Takeda Y, Kanai A, Higashiue S, Kobayashi S, Afuso H, Matsuura K, Mitsumoto Y, Fujita Y, FinnGen, Japan COVID-19 Task Force, Biobank Japan Project, Oda Y, Suzuki Y, Morisaki T, Ishii M, Kitagawa Y, Koike R, Kimura A, Imoto S, Miyano S, Kanai T, Takayama J, Iwasaki M, Sawada N, Fukunaga K, Matsuo K, Kumanogoh A, Doki Y, Eguchi H, Nakagome S, Tamiya G, Ganna A, Palotie A, Daly MJ, Wilson JF, Yamamoto M, Matsuda K, Ogawa S, Yamauchi T, Kadowaki T, Okada Y.   +66 more
europepmc   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Complex peopling history and expansion events inferred from large-scale modern and ancient Y chromosome sequences. [PDF]

Sci Adv
He G, Wang Z, Jiang Y, Yuan H, Luo L, Feng Y, Bu F, Cheng J, Lu Y, Tang R, Liu C, Yuan H, Wang M.   +12 more
europepmc   +1 more source

Y Chromosome [PDF]

, 2019
openaire   +1 more source