Results 171 to 180 of about 10,690,340 (404)
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
Global patterns of sex-biased migrations in humans [PDF]
arXiv, 2013 A series of studies have revealed the among-population components of genetic variation are higher for the paternal Y chromosome than for the maternal mitochondrial DNA (mtDNA), which indicates sex-biased migrations in human populations. However, this phenomenon might be also an ascertainment bias due to nonrandom sampling of SNPs.
arxiv
Eversporting as a Function of the Y-Chromosome in Drosophila Melanogaster [PDF]
, 1933 John W. Gowen, E. H. Gay
openalex +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Y-STR Haplogroup Diversity in the Jat Population Reveals Several Different Ancient Origins
Frontiers in Genetics, 2017 The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people.
David G. Mahal +2 more
doaj +1 more source
Sex chromosome evolution: The classical paradigm and so much beyond [PDF]
arXivSex chromosomes have independently evolved in species with separate sexes in most lineages across the tree of life. However, the well-accepted canonical model of sex chromosome evolution is not universally supported. There is no single trajectory for sex chromosome formation and evolution across the tree of life, suggesting the underlying mechanisms ...
arxiv
Chaos in the Y-chromosome evolution? [PDF]
arXiv, 2016 The Y-chromosome degeneration is still an intriguing mechanism and comprises the very origin of sex. We present a coupled version of the well known logistic map and the logistic equation describing the evolution of XY chromosomes. Although chaos was found in X, Y chromosomes do not evolve chaotically.
arxiv
THE STRUCTURE OF THE Y CHROMOSOME IN THE SALIVARY GLANDS OF DROSOPHILA MELANOGASTER [PDF]
, 1937 A. A. Prokofyeva-Belgovskaya
openalex +1 more source
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Y chromosome in Turner syndrome
Pediatric Endocrinology Diabetes and Metabolism, 2017 Turner syndrome (TS) is an inherited genetic disorder caused by numerical and/or structural chromosome X aberrations occurring at a frequency of 1:1200-1:2500 live-born girls. The most common karyotype is X chromosome monosomy (45,X) (approximately 50-60% of cases).
Marek Niedziela +4 more
openaire +2 more sources