Results 191 to 200 of about 436,984 (262)

Y chromosome variation and prostate cancer ancestral disparities. [PDF]

iScience
Soh PXY, Adams A, Bornman MSR, Jiang J, Stricker PD, Mutambirwa SBA, Jaratlerdsiri W, Hayes VM.   +7 more
europepmc   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Mosaic loss of Y chromosome and mortality after coronary angiography. [PDF]

Eur Heart J
Weyrich M, Zewinger S, Sarakpi T, Rasper T, Kleber ME, Cremer S, Zanders L, Fleck F, Siegbahn A, Wallentin L, Abplanalp WT, Nerbas L, Fay S, Eberle AL, Dimmeler S, März W, Speer T, Zeiher AM.   +17 more
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

ybyra: Y-chromosome haplogroup calling using a tree-based scoring method

Pinotti T, McColl H, Sikora M, Czech L.
europepmc   +1 more source

Impact of Y chromosome loss on the risk of Parkinson's disease and progression. [PDF]

EBioMedicine
Wang J, Chen X, Du W, Lin C, Liao Y, Corvol JC, Maple-Grødem J, Campbell MC, Elbaz A, Lesage S, Brice A, Schwarzschild MA, Taba P, Kõks S, Alves G, Tysnes OB, Perlmutter JS, Maiti B, van Hilten JJ, Barker RA, Williams-Gray CH, Scherzer CR, Liu G, International Genetics of Parkinson Disease Progression (IGPP) Consortium.   +23 more
europepmc   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

MosCoverY: A method to estimate mosaic loss of Y chromosome from sequencing coverage data. [PDF]

Am J Hum Genet
Timonina V, Marchal A, Abel L, Cobat A, Fellay J.   +4 more
europepmc   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Concurrent loss of the Y chromosome in cancer and T cells impacts outcome. [PDF]

Nature
Chen X, Shen Y, Choi S, Abdel-Hafiz HA, Basu M, Hoelzen L, Tufano M, Kailasam Mani SK, Ranjpour M, Zhu J, Ramanujan VK, Koltsova EK, Calsavara VF, Knott SRV, Theodorescu D.   +14 more
europepmc   +1 more source