Results 201 to 210 of about 436,984 (262)

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

HSATII RNA-dependent triplex formation in early human embryogenesis as a potential mechanism for Y chromosome loss in Turner syndrome. [PDF]

Front Mol Biosci
Fularski K.
europepmc   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Y-Chromosome Genetic Characterization Supports the Establishment of Calving Centered Protected Areas for Tibetan Antelope Conservation. [PDF]

Ecol Evol
Wang S, Ma J, Cheng R, Li J, Zhang X, Lin Z, Wei Q, Chen J.   +7 more
europepmc   +1 more source

Where Did the Y Chromosome in the Spiny Rat Go, and How Did It Get There? [PDF]

Mol Biol Evol
Okuno M, Matsuoka K, Mochimaru Y, Yamabe T, Okano M, Jogahara T, Toyoda A, Kuroiwa A, Itoh T.   +8 more
europepmc   +1 more source

The Yemeni genetic structure revealed by the Y chromosome STRs. [PDF]

Forensic Sci Med Pathol
Al-Shoba K, Al-Hamadi N, Almohammed EK, Hadi S, Goodwin W, Lazim H.   +5 more
europepmc   +1 more source

Loss of the Y Chromosome in Oral Potentially Premalignant Disorders Predicts Malignant Progression: An Integrative Cross-Species Multi-Cohort Bioinformatic Study. [PDF]

Head Neck
Han R, Poell JB, Conde-Lopez C, Salo T, Kurth I, Brakenhoff RH, Hess J.   +6 more
europepmc   +1 more source

Paternal genomic history and Y-chromosome phylogeny from the Chengdu Plain reveal multiple Indigenous East Asian farmer contributions to ancient Shu and their descendants. [PDF]

BMC Biol
Luo L, Liu Y, Liu Y, Liu Y, Zhong J, Li B, Wang Z, Feng Y, Luo L, Yang T, Huang Y, Tang R, Yuan H, Liu C, Yuan H, Wang M, He G, Zhu B.   +17 more
europepmc   +1 more source

Non-canonical sex chromosome evolution revealed by extreme heterogeneity in homomorphic Y chromosome differentiation in the common frog

Carpentier F, Veltsos P, Unal E, Doucette K, Fontseré R, Brelsford A, Toups M, Perrin N, Ma W.   +8 more
europepmc   +1 more source