Results 221 to 230 of about 22,741,603 (305)

Y-chromosome alteration and its impact on cancer progression and metastasis. [PDF]

Cell Mol Biol Lett
King SA, Jahan M, Prabhakaraalva P, Zaman N, Chaudhary S, Kyprianou N, Tewari AK, Chakraborty G.   +7 more
europepmc   +1 more source

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila. [PDF]

Mol Biol Evol
Fontan A, Lannes R, Fingerhut JM, Flynn JM, Yamashita YM.   +4 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Loss of Y Chromosome and Major Cardiovascular Events in a Prospective Study of Older Men. [PDF]

J Am Coll Cardiol
Hussain SM, Bjurling J, Yu C, Tonkin AM, Reid CM, Tran C, Fransquet P, Halvardson J, Curtis D, McQuilten Z, Beilin LJ, Forsberg LA, McNeil JJ, Lacaze P.   +13 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes. [PDF]

Nat Med
Sato G, Yamamoto Y, Sonehara K, Saiki R, Ojima T, Kanai M, Liu A, Edahiro R, Shirai Y, Namba S, Namkoong H, Hasaegawa T, Koyanagi YN, Kasugai Y, Yamaji T, Nakano S, Genovese G, Sipilä TP, Ghazal A, Tanaka H, Azekawa S, Uwamino Y, Yamamoto K, Suzuki K, Hata T, Uemura M, Takeda Y, Kanai A, Higashiue S, Kobayashi S, Afuso H, Matsuura K, Mitsumoto Y, Fujita Y, FinnGen, Japan COVID-19 Task Force, Biobank Japan Project, Oda Y, Suzuki Y, Morisaki T, Ishii M, Kitagawa Y, Koike R, Kimura A, Imoto S, Miyano S, Kanai T, Takayama J, Iwasaki M, Sawada N, Fukunaga K, Matsuo K, Kumanogoh A, Doki Y, Eguchi H, Nakagome S, Tamiya G, Ganna A, Palotie A, Daly MJ, Wilson JF, Yamamoto M, Matsuda K, Ogawa S, Yamauchi T, Kadowaki T, Okada Y.   +66 more
europepmc   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Complex peopling history and expansion events inferred from large-scale modern and ancient Y chromosome sequences. [PDF]

Sci Adv
He G, Wang Z, Jiang Y, Yuan H, Luo L, Feng Y, Bu F, Cheng J, Lu Y, Tang R, Liu C, Yuan H, Wang M.   +12 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source