Results 231 to 240 of about 22,741,603 (305)

Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers. [PDF]

Life Sci Alliance
Rychlicka-Buniowska E, Sarkisyan D, Horbacz M, Bruhn-Olszewska B, Drężek-Chyła K, Koszyński M, Davies H, Juhas U, Wójcik-Zalewska M, Klich-Rączka A, Kilander L, Ingelsson M, Bukowska-Strakova K, Węglarczyk K, Siedlar M, Baran J, Ryś J, Piotrowski A, Filipowicz N, Dumanski JP.   +19 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Association of Y Chromosome Microdeletions with Reproductive Profiles in 2010 Infertile Male Patients in China. [PDF]

Appl Clin Genet
Chen G, Huang P, Li H, Zheng B, Sun Y.
europepmc   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

The presence of Y chromosome leads to the difference of cancer in patients with different sexes

MedComm
Yingqi Kuang, Wenhuan Sun, Long Zhang
doaj   +1 more source

Integrated mitogenome and Y chromosome analysis untangles the complex origin of African pigs. [PDF]

iScience
Odongo LA, Adeola AC, Msalya GM, Olaniyan OF, Njuki RN, Mauki DH, Ndiema EK, Shi X, Cai ZF, Yin TT, Fu Y, Liu X, Zhao S, Djagoun CAMS, Luka PD, Wanzie NK, Niba G, Oluwole OO, Olaogun SC, Omotosho O, Sanke OJ, Greiner E, Okoro VMO, Omitogun OG, Dawuda PM, Souron A, Xie HB, Agwanda B, Mwacharo JM, Bishop RP, Han JL, Peng MS, Zhang YP.   +32 more
europepmc   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Combined optical genome mapping and cnv-seq identify complex Y-chromosome rearrangements and ectopy in 46,XX testicular disorder of sex development. [PDF]

Mol Cytogenet
Wang H, Wang H, Xu Z, Chen P, Zheng X, Pan H, Zhang H, Zheng J.   +7 more
europepmc   +1 more source