A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang +4 more
wiley +1 more source
Directed Motion and Spatial Coherence in the Cell Nucleus [PDF]
arXivInvestigating the dynamics of chromatin and the factors that are affecting it, has provided valuable insights into the organization and functionality of the genome in the cell nucleus. We control the expression of Lamin-A, an important organizer protein of the chromatin and nucleus structure.
arxiv
Inheritance of Ddt-Resistance Involving The Y-Chromosome in the Housefly (Musoa Domestioa L.) [PDF]
, 1961 RW Kerr
openalex +1 more source
Cytological studies on mosses from Papua New Guinea : 1., introduction and the family Orthotrichaceae. [PDF]
, 1995 Chromosome numbers with information on meiotic behaviour are recorded for the first time for the following taxa in the family Orthotrichaceae from Papua New Guinea - Desmotheca apiculata (Dozy & Molk.) Lindb. ex Card.
Ramsay, Helen P. +2 more
core
Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Approximately half of patients with hereditary myopathies remain without a definitive genetic diagnosis after DNA next‐generation sequencing (NGS). Here, we implemented transcriptome analysis of muscle biopsies as a complementary diagnostic tool for patients with muscle disease but no definitive genetic diagnosis after exome ...
Alba Segarra‐Casas +24 more
wiley +1 more source
Tests for an effect of the Y-chromosome on the mutagenic action of formaldehyde and X-rays in Drosophila melanogaster [PDF]
, 1968 Winston E. Ratnayake
openalex +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Inherited pericentric inversion of a human Y chromosome in trisomic Down's syndrome. [PDF]
, 1970 R S Sparkes +2 more
openalex +1 more source
Advanced Science, EarlyView.Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang +17 more
wiley +1 more source
Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Advanced Science, EarlyView.Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou +8 more
wiley +1 more source